Results 221 to 230 of about 26,828 (241)
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Ethylene Formation in Rat Liver Microsomes
Science, 1966Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
Paul Hochstein, Morris Lieberman
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Metabolism of naphthalene by pigeon liver microsomes
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979Abstract 1. Microsomal mixed-function oxidase of the pigeon liver shows maximum activity and stability at 44°C and 6.8 pH. Naphthalene is metabolized to 1-naphthol and 1,2-diol and a number of minor metabolites. The MFO activity and P-450 contents of pigeon liver microsomes, under optimum conditions show about 1 3 to 1 4 activity of ...
M.A.Q. Khan, J.C. Grossman
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THE MECHANISM OF SCHRADAN ACTIVATION BY LIVER MICROSOMES
Canadian Journal of Biochemistry and Physiology, 1957The mechanism by which schradan is converted to a powerful anticholinesterase by fortified liver homogenates has been studied. A scheme is proposed involving the production from DPNH of hydrogen peroxide, which then oxidizes an unknown microsomal factor with the aid of catalase. The factor in turn oxidizes schradan.
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Kavalactone Metabolism in Rat Liver Microsomes
Phytotherapy Research, 2011The specific CYP enzymes involved in kavalactone (KLT) metabolism and their kinetics have not been fully examined. This study used rat liver microsomes (RLM) to determine kavain (KA), methysticin (MTS) and desmethoxyyangonin (DMY) enzyme kinetic parameters, to elucidate the major CYP450 isoforms involved in KLT metabolism and to examine gender ...
Anthony Rowe, Iqbal Ramzan, Shuang Fu
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The mechanism of liver microsomal lipid peroxidation
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975In the presence of Fe-3+ and complexing anions, the peroxidation of unsaturated liver microsomal lipid in both intact microsomes and in a model system containing extracted microsomal lipid can be promoted by either NADPH and NADPH : cytochrome c reductase or by xanthine and xanthine oxidase.
Steven D. Aust, Thomas C. Pederson
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Metabolism of Dietary Flavonoids in Liver Microsomes
Current Drug Metabolism, 2013Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4'-, C-3', C-6 and C-8- position when there is a single or no hydroxy group ...
Jianbo Xiao, Petra Högger
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
Donald D. Koblin +2 more
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FRACTIONATION OF MOUSE LIVER MICROSOMAL ESTERASES
Canadian Journal of Biochemistry, 1965Mouse liver microsomal esterases were fractionated on DEAE-cellulose after the solution of these enzymes in a solution containing 0.1 M glycyl glycine buffer, pH 7.0, and 5 × 10−4 M Lubrol W, a nonionic detergent. Elution of the enzymes from the DEAE-cellulose was accomplished by using NaCl in the glycyl glycine – Lubrol W solution.
C. Carruthers, E. Heins, A. Baumler
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A microsomal exoribonuclease from rat liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1979A exoribonuclease has been purified from the microsomes of rat liver. The enzyme had an apparent molecular weight of 80 000-83 000 and produced, via a processive mechanism, 5'-AMP as the only product from poly(A). The degradation was found to proceed in the 3' to 5' direction.
Kazuei Igarashi +4 more
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Esterification of cholesterol in rat liver microsomes
Archives of Biochemistry and Biophysics, 1964Washed rat liver microsomes esterify cholesterol in the presence of added ATP and CoA; net synthesis of cholesterol esters was demonstrated. The optimum pH of the reaction was between 6.8 and 7.2; the effects of time and concentration of substrate were investigated.
M.D. Law +5 more
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