Results 231 to 240 of about 64,891 (274)
Some of the next articles are maybe not open access.
Interaction of ranitidine with liver microsomes
Xenobiotica, 19821. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić +3 more
openaire +2 more sources
Microsomal monooxygenase system in frog livers
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984Liver microsomes prepared from four species of frog, Rana catesbeiana, Rana nigromaculata , Bufo bufo japonicus, and Xenopus laevis, contained cytochrome P-450 and showed NAD(P)H-dependent monooxygenase activities to several foreign chemical compounds tested.
M, Noshiro, T, Omura
openaire +2 more sources
Benzene metabolism in mouse liver microsomes
Toxicology and Applied Pharmacology, 1973Abstract Mouse liver microsomes metabolized benzene more rapidly than microsomes prepared from rat and rabbit liver. Treatment of mice with benzene increased the metabolism of benzene in vitro without increasing cytochrome P-450 concentrations. Conversely, treatment of mice with phenobarbital increased cytochrome P-450 values but did not increase ...
L M, Gonasun +3 more
openaire +2 more sources
Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes
Biochemical Pharmacology, 1981Abstract The carcinogen nitrosoacetoxymethylmethylamine (NAMM)‡ was incubated with mouse liver microsomes. The decomposition rate of NAMM and the formation of methanol were determined. After addition of an NADPH-regenerating system, formaldehyde formation resulting from metabolic degradation of the methyl group of NAMM was measured.
K E, Appel, N, Frank, M, Wiessler
openaire +2 more sources
Interaction of Cimetidine with Liver Microsomes
Xenobiotica, 19791. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić +4 more
openaire +2 more sources
Permeability of Liver Microsomal Membranes to Glucose
Biochemical and Biophysical Research Communications, 1996The permeability of rat liver microsomes to glucose has been studied by using (14)C-labelled D-glucose and a light-scattering technique. 1) The microsomal intravesicular apparent isotope space for D-glucose (1mM; after 5 min incubation at 22 degrees C) was 2.34 microl/mg protein, i.e., approximately 72% of the apparent water space.
MARCOLONGO, P. +4 more
openaire +4 more sources
Fumonisin B1 Metabolism by Bovine Liver Microsomes
Veterinary Research Communications, 2001Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
M. SPOTTI, G. POMPA, F. CALONI
openaire +3 more sources
Characteristics of extracts from liver microsomes
Experimental Cell Research, 1957Abstract When rat liver microsomes are treated at 1–3 °C with 0.1–0.2 M bicarbonate buffer, pH 8.2–8.4, about 70 per cent of the ribonucleic acid is gradually released from the particles together with some protein. The extracted microsome residues can be largely brought into solution by treatment with deoxycholate or other detergents. The properties
openaire +2 more sources
Human liver microsomal drug metabolism
Biochemical Pharmacology, 1970F J, Darby, W, Newnes, D A, Price Evans
openaire +2 more sources
Activation of Thionophosphates by Liver Microsomes
Nature, 1959MANY organophosphorus insecticides are poor inhibitors of cholinesterase, but are converted to potent inhibitors (‘activated’) by certain mammalian and insect tissues. The activation by liver slices was first shown by Gardiner and Kilby1 for schradan (a phosphoroamidate), and by Diggle and Gage2 for parathion (a phosphorothionate). Davison3 showed that
openaire +2 more sources