Results 31 to 40 of about 1,685,497 (299)

Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]

, 2010
Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon
core   +2 more sources

Oxidative metabolism of BDE-99 by human liver microsomes: predominant role of CYP2B6.

Toxicological Sciences, 2012
Hydroxylated polybrominated diphenyl ethers (PBDEs) have been found in human serum, suggesting that they are formed by in vivo oxidative metabolism of PBDEs.
C. Erratico, A. Szeitz, S. Bandiera
semanticscholar   +1 more source

Morphine Metabolism in Human Skin Microsomes [PDF]

, 2012
For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S., Küchler, Sarah, Schäfer-Korting, Monika   +2 more
core   +2 more sources

Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin

Toxins, 2022
Beauvericin (BEA) is a well-known mycotoxin produced by many fungi, including Beaveria bassiana. The purpose of this study was to evaluate the in vitro distribution and metabolism characteristics as well as the in vivo pharmacokinetic (PK) profile of BEA.
Yu Yuan, Guangpeng Meng, Yuanbo Li, Chunjie Wu   +3 more
doaj   +1 more source

Comparing Soy and Milk Protein Regulation of Hepatic Omega-3 Fatty Acid Biosynthesis. [PDF]

FASEB J
EPA and DHA are omega‐3 fatty acids with anti‐inflammatory and triglyceride‐lowering properties. They are obtained from fatty fish or synthesized in the liver from ALA. Male C57BL/6N mice were fed a diet containing soy protein isolate or skim milk powder and 1% or 3% energy from ALA for 8 weeks.
Gonzalez-Soto M, Woods SE, MacLeod BW, Smorenburg JN, DesOrmeaux GJ, Holloway GP, Rotarescu RD, Green MR, Metherel AH, Mutch DM.   +9 more
europepmc   +2 more sources

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

Chemical Research in Toxicology, 2012
Isoniazid (INH) is associated with serious liver injury and autoimmunity. Classic studies in rats indicated that a reactive metabolite of acetylhydrazine is responsible for the covalent binding and toxicity of INH.
Imir G. Metushi, T. Nakagawa, J. Uetrecht   +2 more
semanticscholar   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Effect of blood plasma lipoproteins on hydroxylation of benzo[a]pyrene in liver microsomes of rats

Атеросклероз, 2020
This work presents the characteristics of the catalytic activity of hydroxylation of benzo[a] pyrene (B[a]P) in rat liver microsomes using plasma lipoproteins (LP) (VLDL, LDL, HDL) as transport forms of B[a]P.
L. M. Polyakov, R. A. Knyazev, N. V. Trifonova, M. V. Kotova, E. I. Solovyova, A. V. Ryabchenko   +5 more
doaj   +1 more source

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

The metabolism of gelsevirine in human, pig, goat and rat liver microsomes

Veterinary Medicine and Science, 2021
Gelsemium is a small genus of flowering plants from the family Loganiaceae comprising five species, three of which, Gelsemium sempervirens (L.) J. St.‐Hil., G. elegans Benth and G. rankinii Small, are particularly popular.
Hua‐Hai Zhang, Wen‐Jia Yang, Ya‐Jun Huang, Wen‐Jing Li, Shuo‐Xin Zhang, Zhao‐Ying Liu   +5 more
doaj   +1 more source