Results 31 to 40 of about 26,828 (241)
GC–MS analysis of oxysterols and their formation in cultivated liver cells (HepG2)
Lipids, Volume 58, Issue 1, Page 41-56, January 2023., 2023 Abstract Oxysterols play a key role in many (patho)physiological processes and they are potential biomarkers for oxidative stress in several diseases. Here we developed a rapid gas chromatographic‐mass spectrometry‐based method for the separation and quantification of 11 biologically relevant oxysterols bearing hydroxy, epoxy, and dihydroxy groups ...
Elisabeth Koch +6 more
wiley +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Effect of blood plasma lipoproteins on hydroxylation of benzo[a]pyrene in liver microsomes of rats
Атеросклероз, 2020 This work presents the characteristics of the catalytic activity of hydroxylation of benzo[a] pyrene (B[a]P) in rat liver microsomes using plasma lipoproteins (LP) (VLDL, LDL, HDL) as transport forms of B[a]P.
L. M. Polyakov +5 more
doaj +1 more source
The metabolism of gelsevirine in human, pig, goat and rat liver microsomes
Veterinary Medicine and Science, 2021 Gelsemium is a small genus of flowering plants from the family Loganiaceae comprising five species, three of which, Gelsemium sempervirens (L.) J. St.‐Hil., G. elegans Benth and G. rankinii Small, are particularly popular.
Hua‐Hai Zhang +5 more
doaj +1 more source
Liver Tumor Prediction with Advanced Attention Mechanisms Integrated into a Depth-Based Variant Search Algorithm [PDF]
, 2023 In recent days, Deep Learning (DL) techniques have become an emerging transformation in the field of machine learning, artificial intelligence, computer vision, and so on. Subsequently, researchers and industries have been highly endorsed in the medical field, predicting and controlling diverse diseases at specific intervals.
arxiv +1 more source
Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023 Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman +6 more
wiley +1 more source
Liver segmentation and metastases detection in MR images using convolutional neural networks [PDF]
J. Med. Imag. 6(4), 044003 (2019), 2019 Primary tumors have a high likelihood of developing metastases in the liver and early detection of these metastases is crucial for patient outcome. We propose a method based on convolutional neural networks (CNN) to detect liver metastases. First, the liver was automatically segmented using the six phases of abdominal dynamic contrast enhanced (DCE) MR
arxiv +1 more source
Molecular Informatics, Volume 41, Issue 12, December 2022., 2022 Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco +2 more
wiley +1 more source
Pharmaceutics, 2021 DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ).
Sin-Eun Kim +13 more
doaj +1 more source
Molecular Nutrition &Food Research, Volume 66, Issue 24, December 2022., 2022 Duodenal mucosa in early‐stage type 2 diabetes mellitus (ED), late‐stage type 2 diabetes mellitus injected with streptozotocin‐nicotinamide (STZ/NAD) (LD) and treated‐silicon LD (LD‐Si) groups. Silicon partially reversed LD group alterations: decreased absorptive area and acyl‐Coenzyme A:cholesterol acyltransferase 2 (ACAT2) levels, and increased ...
Marina Hernández‐Martín +9 more
wiley +1 more source