Results 71 to 80 of about 1,677,689 (317)
Nucleotide Activation of Liver Microsomal Glucuronidation
Journal of Biological Chemistry, 1961 6 páginas en ...
Pogell, Burton M., Leloir, Luis Federico
openaire +3 more sources
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]
, 2018 BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K +6 more
core
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]
, 2013 Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y. +4 more
core +3 more sources
The Association of Deoxyribonucleic Acid with Liver Microsomes
Journal of Biological Chemistry, 1969 Abstract Rats and mice were given 3H-thymidine, and 18 to 24 hours later nuclei, mitochondria, and microsomes were isolated from the livers by differential centrifugation. The nucleic acids were extracted from the fractions by means of the phenol-sodium dodecyl sulfate procedure.
Schneider, W C, Kuff, E L
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Advanced NanoBiomed Research, EarlyView.Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo +2 more
wiley +1 more source
Efficient liver segmentation with 3D CNN using computed tomography scans [PDF]
arXiv, 2022 The liver is one of the most critical metabolic organs in vertebrates due to its vital functions in the human body, such as detoxification of the blood from waste products and medications. Liver diseases due to liver tumors are one of the most common mortality reasons around the globe.
arxiv
Online Domain Adaptation for Continuous Cross-Subject Liver Viability Evaluation Based on Irregular Thermal Data [PDF]
arXiv, 2020 Accurate evaluation of liver viability during its procurement is a challenging issue and has traditionally been addressed by taking invasive biopsy on liver. Recently, people have started to investigate on the non-invasive evaluation of liver viability during its procurement using the liver surface thermal images.
arxiv
Do Flame Retardants Promote Vitamin D Deficiency? [PDF]
, 2014 Vitamin D deficiency in the Unites States has become more prevalent in recent years. Research has shown that environmental chemicals such as flame-retardants induce hepatic enzymes in the cytochrome P450 family such as CYP24 and CYP3A that are important ...
Petteruti, Audrey
core +2 more sources
UPLC-MS/MS analysis of ochratoxin A metabolites produced by Caco-2 and HepG2 cells in a co-culture system [PDF]
, 2017 Ochatoxin A (OTA) is one of the most important mycotoxins based on its toxicity. The oral route is the main gateway of entry of OTA into the human body, and specialized epithelial cells constitute the first barrier.
González Arias, Cyndia A. +4 more
core +2 more sources