Results 81 to 90 of about 81,174 (219)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo +5 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Adult patients with anaplastic lymphoma kinase positive (ALK+) advanced non–small‐cell lung cancer (NSCLC) are treated with 600 mg alectinib twice daily (BID) as first‐line treatment. ALK positive solid and central nervous system (CNS) tumors are described in the pediatric population, with limited clinical data due to the rarity of the disease
Tamara van Donge +6 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu +12 more
wiley +1 more source
Pediatric Autoimmune Pancreatitis: Clinical Findings and Outcomes in Sweden
United European Gastroenterology Journal, EarlyView.ABSTRACT Introduction Pediatric autoimmune pancreatitis (AIP) is a rare form of pancreatitis in children with poorly understood pathophysiology. It is a recognized risk factor for chronic pancreatitis in approximately 4% of pediatric cases. This study aims to describe the demographics, clinical characteristics, and outcomes of a large Swedish cohort of
Miroslav Vujasinovic +9 more
wiley +1 more source
Integrative Zoology, EarlyView.The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang +5 more
wiley +1 more source
Journal of Digestive Diseases, EarlyView.Mycophenolate mofetil (MMF) demonstrates superior efficacy and tolerability compared to azathioprine (AZA) in treatment‐naïve autoimmune hepatitis (AIH) patients. Meta‐analysis of five studies reveals higher complete biochemical response rates, increased Corticosteroid withdrawal rate, and fewer gastrointestinal side effects with MMF.
Muhammad Tayyab Anwar +12 more
wiley +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Genotoxic Herbicide Exposures in Golden Retrievers With and Without Multicentric Lymphoma. [PDF]
Vet Comp OncolABSTRACT Canine multicentric lymphoma (CML) is one of the most common malignancies in dogs. Although breed risk is important, environmental factors such as herbicides have also been implicated. The objective of this study was to determine whether genotoxic exposures to the herbicides 2,4‐D and glyphosate are associated with CML, using dogs from the ...
Tindle AN +6 more
europepmc +2 more sources
A Microsomal Nucleoside Diphosphatase
Journal of Biological Chemistry, 1963 Margareta Heus, Alex B. Novikoff
openaire +3 more sources
Opportunities of patient‐derived organoids in drug development
British Journal of Pharmacology, EarlyView.Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley +1 more source