Results 81 to 90 of about 35,679 (167)

Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies. [PDF]

Cell Biol Toxicol
Wang P, Fu H, Wu J, Li R, Cao L, Xu RA, Lin W.   +6 more
europepmc   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Discovery of <i>N</i>-Acetyltransferase 8-Like (NAT8L) inhibitors based on a <i>N</i>-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold. [PDF]

ACS Med Chem Lett
Nayeen MJ, Thomas AG, Kundu B, Carlyle E, Hin N, Hin P, Pal A, Paule J, Rais R, Slusher BS, Tsukamoto T.   +10 more
europepmc   +1 more source

Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Liver cirrhosis is accompanied by pathophysiological changes. Due to multiple absorption, distribution, metabolism and excretion (ADME)‐related pathophysiological alterations, the estimation of the net pharmacokinetics (PK) change in cirrhotic patients is complex.
Annika R. P. Schneider, Vanessa Baier, Jan‐Frederik Schlender, Lars Kuepfer   +3 more
wiley   +1 more source

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and <i>in Vivo</i> in Mice. [PDF]

ACS Med Chem Lett
Simon KT, Hailemariam SE, Friedman E, Wen YW, Freaney M, Barker-Haliski M, Isoherranen N.   +6 more
europepmc   +1 more source

Immunostaining of P450c17, Aromatase and Oestrogen Receptor Alpha in Germ and Somatic Cells During Gonadal Development in Greater Rhea

Anatomia, Histologia, Embryologia, Volume 55, Issue 2, March 2026.
ABSTRACT The greater rhea (Rhea americana), the largest bird species in South America, has significant economic value due to its meat, eggs, leather, feathers and oil. However, its lack of external sexual dimorphism poses challenges for reproductive management and breeding programmes.
Marilú Cristofoli, Danielle Cristina Calado de Brito, Mayla Magalhães de Oliveira Alcobaça, Flavia Maria Pia Montenegro Donoso, Fabiana Morse Gosson Jorge, Marco Aurélio Schiavo Novaes, Moacir Franco Oliveira, Antônio Chaves de Assis Neto   +7 more
wiley   +1 more source

Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii. [PDF]

BMC Genomics
Muhammad A, Ibrahim SS, Ismail HM, Irving H, Paine MJI, Wondji CS.   +5 more
europepmc   +1 more source

Design, Synthesis, and Evaluation of Bis‐Chalcones and Bis‐Flavones as Selective COX‐2 Inhibitors

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Rui Pereira, Marisa Freitas, Alberto N. Araújo, Vera L. M. Silva, Eduarda Fernandes   +4 more
wiley   +1 more source

Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. [PDF]

J Med Chem
Valderrama K, Horlacher O, Publicola G, Eisenring P, Kienle M, Boarbi S, Kiass M, Korduláková J, Chatagnon J, Piveteau C, Leroux F, Savková K, Záhorszká M, Cantrelle FX, Lherbet C, Mourey L, Mikušová K, Mathys V, Aichholz R, Maveyraud L, Altmann KH, Hartkoorn RC.   +21 more
europepmc   +1 more source

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, Volume 249, Issue 5, Page 2196-2214, March 2026.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source