The Function of Autophagy as a Regulator of Melanin Homeostasis
Cells, 2022 Melanosomes are melanocyte-specific organelles that protect cells from ultraviolet (UV)-induced deoxyribonucleic acid damage through the production and accumulation of melanin and are transferred from melanocytes to keratinocytes.
Ki Won Lee +3 more
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Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly [PDF]
, 2009 Mitotic spindle formation and chromosome segregation depend critically on kinetochore-microtubule (KT-MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C.
Erich A. Nigg +15 more
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Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]
, 2013 Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg +16 more
core +1 more source
Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]
, 2014 EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma +2 more
core +1 more source
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]
, 2010 We have studied Sds22, a conserved regulator of protein phosphatase 1 (PP1) activity, and determined its role in modulating the activity of aurora B kinase and kinetochore-microtubule inter-actions.
DeLuca, Jennifer G. +11 more
core +1 more source
Cells, 2020 High mobility group box-1 (HMGB1), a nonhistone chromatin DNA-binding protein, is released from neurons into the extracellular space under ischemic, hemorrhagic, and traumatic insults. However, the details of the time-dependent translocation of HMGB1 and
Dengli Wang +7 more
doaj +1 more source
The kinesin-12 Kif15 is a processive track-switching tetramer [PDF]
, 2014 Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
McHugh, Toni +9 more
core +1 more source
Theiler's murine encephalomyelitis protein 2C and its effect on membrane trafficking [PDF]
, 2008 Picornaviruses replicate in association with cytoplasmic membranes of infected cells. Poliovirus 2C and 2BC play an important role in the formation of membranous vesicles, and induce dramatic changes in membrane trafficking.
Moës, Elien
core +2 more sources
mRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines
Data in Brief, 2016 We characterized the dynamics of autophagy in vitro using four different cell systems and analyzing markers widely used in this field, i.e. LC3 (microtubule-associated protein 1 light chain 3; protein recruited from the cytosol (LC3-I) to the ...
Rubén Gómez-Sánchez +9 more
doaj +1 more source
Propofol elicits autophagy via endoplasmic reticulum stress and calcium exchange in C2C12 myoblast cell line. [PDF]
PLoS ONE, 2018 In this study, we investigated the relationship between propofol and autophagy and examined whether this relationship depends on ER stress, production of ROS (reactive oxygen species), and disruption of calcium (Ca2+) homeostasis.
Xi Chen +7 more
doaj +1 more source