Results 111 to 120 of about 262,894 (312)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Ultrasensitivity of microtubule severing due to damage repair

iScience
Summary: Microtubule-based cytoskeletal structures aid in cell motility, cell polarization, and intracellular transport. These functions require a coordinated effort of regulatory proteins which interact with microtubule cytoskeleton distinctively.
Chloe E. Shiff, Jane Kondev, Lishibanya Mohapatra   +2 more
doaj   +1 more source

New insights into the functions and regulations of MAP215/MOR1 and katanin, two conserved microtubule-associated proteins in Arabidopsis. [PDF]

Plant Signal Behav, 2023
Liu X, Yu F.
europepmc   +1 more source

Neuronal-associated microtubule proteins class III β-tubulin and MAP2c in neuroblastoma: Role in resistance to microtubule-targeted drugs [PDF]

, 2004
Sima Don, Nicole M. Verrills, Tracy Y.E. Liaw, Marjorie L. M. Liu, Murray D. Norris, Michelle Haber, Maria Kavallaris   +6 more
openalex   +1 more source

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. [PDF]

, 2019
The unidirectional and opposite-polarity microtubule-based motors, dynein and kinesin, drive long-distance intracellular cargo transport. Cellular observations suggest that opposite-polarity motors may be coupled.
Dickey, Andrea M, Dzieciatkowska, Monika, Harper, J Wade, Kendrick, Agnieszka A, Reck-Peterson, Samara L, Redwine, William B, Tran, Phuoc Tien, Vaites, Laura Pontano   +7 more
core  

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Corrigendum: Cellular cartography: towards an atlas of the neuronal microtubule cytoskeleton

Frontiers in Cell and Developmental Biology, 2023
Malina K. Iwanski, Lukas C. Kapitein
doaj   +1 more source

GTSE1 promotes the growth of NSCLC by regulating microtubule-associated proteins through the ERK/MAPK pathway. [PDF]

Thorac Cancer, 2023
Wang C, Wen M, Xu J, Gao P, Liu S, Liu J, Chen Y, Zhou L.   +7 more
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Griseofulvin Inhibits Root Growth by Targeting Microtubule-Associated Proteins Rather Tubulins in Arabidopsis. [PDF]

Int J Mol Sci, 2023
Guo Y, Li J, Shi J, Mi L, Zhang J, Han S, Liu W, Cheng D, Qiang S, Kalaji HM, Chen S.   +10 more
europepmc   +1 more source