Results 131 to 140 of about 175,942 (250)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

An atlas of novel microtubule-associated proteins in the malaria parasite <i>Plasmodium falciparum</i>. [PDF]

mBio
Niedermüller K, Piwon N, Mesen-Ramirez JP, Zink L, Lemcke S, Liffner B, Fernandes CF, Farias GB, Alder A, Löw C, Dahan N, Wilson DW, Cubillán-Marín J, Gilberger TW.   +13 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

PM_2.5-Induced Multinucleation of Bronchial Epithelial Cells due to Microtubule Overacetylation and Disruption of Microtubule-Associated Proteins. [PDF]

Environ Health (Wash)
Xiao L, Pang J, Guo Z, Zhang K, Xiong Z, Yang M, Wang J, Li Y, Lynch I.   +8 more
europepmc   +1 more source

A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse. [PDF]

PLoS Genet, 2020
Leca I, Phillips AW, Hofer I, Landler L, Ushakova L, Cushion TD, Dürnberger G, Stejskal K, Mechtler K, Keays DA.   +9 more
europepmc   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders. [PDF]

Neurotox Res
Becher MK, Avdoshina V, Campbell LA, Mocchetti I.   +3 more
europepmc   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Molecular and Genetic Analysis of the Increased Number of Genes for <i>Trypanosoma cruzi</i> Microtubule Associated Proteins in the Class Kinetoplastida. [PDF]

Pathogens
Winkler MA, Pan AA.
europepmc   +1 more source

Acetylation/deacetylation and microtubule associated proteins influence flagellar axonemal stability and sperm motility. [PDF]

Biosci Rep, 2020
Chawan V, Yevate S, Gajbhiye R, Kulkarni V, Parte P.   +4 more
europepmc   +1 more source