Results 91 to 100 of about 453,492 (382)

Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport [PDF]

, 2010
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells.
A Peaucelle, A. C Newell, A. J Fleming, A. R Paredez, A. R Paredez, C Lloyd, Carolyn Ohno, D Reinhardt, D Reinhardt, D. D Fisher, E. J Chapman, E. M Bayer, Elliot M. Meyerowitz, F Corson, F. A Ditengou, G. J Mitchison, G. V Reddy, H Jonsson, Henrik Jönsson, J Craft, J Friml, J Marc, J Petrasek, J. A Raven, Jan Traas, K Okada, M. G Heisler, Magalie Uyttewaal, Marcus G. Heisler, N Geldner, N. C Shaner, O Grandjean, O Hamant, Olivier Hamant, Ottoline Leyser, P Sahlin, P. B de Reuille, P. H Rubery, Pawel Krupinski, R Gutierrez, R Himmelspach, R. E Peterson, R. E Williamson, R. S Smith, S Douady, S Sakaguchi, W. R Scheible, Y Boutte, Y Cheng   +48 more
core   +5 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Diffusion of myosin V on microtubules [PDF]

, 2011
Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma, Schliwa, Manfred, Voith von Voithenberg, Lena, Zimmermann, Dennis, Ökten, Zeynep   +4 more
core   +1 more source

Microtubule‐Associated‐Protein MAP1 is not Implicated in the Polymerization of Microtubules [PDF]

European Journal of Biochemistry, 1980
Addition of DNA to microtubule protein solutions results in a decrease of the amount of the high‐molecular‐weight microtubule‐associated proteins (MAP1 and MAP2) available for polymerization. Complete removal of MAP1 from microtubules requires lower concentrations of DNA compared to MAP2.
Villasante, Alfredo, Torre, Javier de la, Manso-Martínez, Rafael, Ávila, Jesús   +3 more
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

eLife, 2015
Kinetochore fibers (K-fibers) of the mitotic spindle are force-generating units that power chromosome movement during mitosis. K-fibers are composed of many microtubules that are held together throughout their length.
Faye M Nixon, Cristina Gutiérrez-Caballero, Fiona E Hood, Daniel G Booth, Ian A Prior, Stephen J Royle   +5 more
doaj   +1 more source

MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]

, 2018
Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le, Tymanskyj, Stephen R., Verhey, Kristen J., Yang, Benjamin   +3 more
core   +1 more source

The preprophase band-associated kinesin-14 OsKCH2 is a processive minus-end-directed microtubule motor. [PDF]

, 2018
In animals and fungi, cytoplasmic dynein is a processive minus-end-directed motor that plays dominant roles in various intracellular processes. In contrast, land plants lack cytoplasmic dynein but contain many minus-end-directed kinesin-14s.
Bowen, Joel, Gicking, Allison M, Guo, Lijun, Lee, Yuh-Ru Julie, Liu, Bo, Qiu, Weihong, Tseng, Kuo-Fu, Wang, Pan   +7 more
core   +3 more sources

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

Nature Communications, 2016
Neurons display a highly polarized microtubule network that mediates trafficking throughout the extensive cytoplasm and is crucial for neuronal differentiation and function.
Carlos Sánchez-Huertas, Francisco Freixo, Ricardo Viais, Cristina Lacasa, E. Soriano, Jens Lüders   +5 more
semanticscholar   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source