Results 41 to 50 of about 359,607 (329)

The life of a microtubule

Molecular Biology of the Cell, 2018
The Minisymposium “The Life of a Microtubule: Birth, Dynamics and Function†highlighted new findings on how microtubules (MTs) are made, how their length and spatial organization is regulated, and finally how they contribute to cellular functions.
Dixit, Ram, Petry, Sabine
openaire   +4 more sources

Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching

eLife, 2015
The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated sister kinetochores. Sister kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin.
Nigel J Burroughs, Edward F Harry, Andrew D McAinsh   +2 more
doaj   +1 more source

Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin [PDF]

, 2012
Microtubule severing enzymes regulate microtubule dynamics in a wide range of organisms and are implicated in important cell cycle processes such as mitotic spindle assembly and disassembly, chromosome movement and cytokinesis.
A Baines, A Errico, A Hemphill, A Karabay, A Roll-Mecak, A Roll-Mecak, A Schneider, A Schneider, A Woods, B Lacroix, B Wickstead, C Benz, C Hertz-Fowler, C Lu, C Vedrenne, Caroline Clucas, Corinna Benz, D Buster, D Spitznagel, D Zhang, D Zhang, Dan Zilberstein, DJ LaCount, DR Robinson, E Detmer, E Panteris, E Wirtz, EE Dymek, FJ Ahmad, FJ McNally, FJ McNally, G Burkard, GR Forsythe, H Sudo, H Sudo, H Sudo, HH Lee, HP Price, J Guizetti, J Van den Abbeele, JA Garcia-Salcedo, JA Schiel, JC Munday, JD Diaz-Valencia, Jeremy C. Mottram, JJ Hartman, JJ Hartman, JT Ma, JW Connell, K Gull, K McNally, K Toyo-oka, KJ Evans, KP Mcnally, KP McNally, KP Mcnally, KR Matthews, KY Chan, L Kohl, L Qiang, L Rindisbacher, M Agromayor, M Casanova, M Srayko, MQ Rasi, MR Dow, N Balaban, N Balaban, N Sharma, P Bastin, Q Meng, R Sasse, R Sharma, S Biebinger, S Kelly, S Monnerat, S Olego-Fernandez, S Redmond, S Vaughan, SG Lillico, SH Park, T Sherwin, T Sherwin, T Sherwin, Tansy C. Hammarton, TC Hammarton, TC Hammarton, TC Hammarton, TC Hammarton, W Yu, WQ Yu, Z Li, Z Li   +92 more
core   +5 more sources

Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation

, 2017
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Foster, Peter J., Fürthauer, Sebastian, Kaye, Bryan, Needleman, Daniel J., Shelley, Michael J., Stiehl, Olivia   +5 more
core   +1 more source

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source

27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells

eLife, 2017
Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle in mammalian cells can be aligned by magnetic field has not been experimentally proved.
Lei Zhang, Yubin Hou, Zhiyuan Li, Xinmiao Ji, Ze Wang, Huizhen Wang, Xiaofei Tian, Fazhi Yu, Zhenye Yang, Li Pi, Timothy J Mitchison, Qingyou Lu, Xin Zhang   +12 more
doaj   +1 more source

Microtubules born on microtubules

The Journal of Cell Biology, 2005
![Graphic][1] A new MT is nucleated (white arrowhead) by a γ-TuC (green) that sits on an existing MT bundle.Microtubule (MT) arrays form, say Janson et al. ( [page 297][2]), when MT nucleators stick to existing MTs.
openaire   +3 more sources

Microtubules gate tau condensation to spatially regulate microtubule functions. [PDF]

, 2019
Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear.
A Ettinger, A Hernandez-Vega, A Kremer, A Seitz, Aileen J. Lam, AR Duan, B Niewidok, BY Monroy, Dan W. Nowakowski, DP McVicker, DP McVicker, EH Kellogg, H Hagiwara, H Zempel, HT Hoang, J Baumbach, JA Garcia-Leon, Jisoo Han, K Tepper, Kassandra M. Ori-McKenney, KM Ori-McKenney, KS Hubbard, L Qiang, L Urnavicius, LC Kapitein, M Goedert, M Vershinin, M Vershinin, MH Hinrichs, Michael Vershinin, PA Gutierrez, R Dixit, R Zhang, RD Vale, Richard J. McKenney, RJ McKenney, RJ McKenney, Ruensern Tan, S Ambadipudi, S Konzack, S Wegmann, S Wegmann, Sergi Simó, SR White, Tracy Tan, V Makrides, W Yu, XH Li   +47 more
core   +1 more source

Monitoring Microtubule Mechanical Vibrations via Optomechanical Coupling

, 2016
The possible disruption of a microtubule during mitosis can control the duplication of a cancer cell. Cancer detection and treatment may be possible based on the detection and control of microtubule mechanical oscillations in cells through external ...
Barzanjeh, Sh., Cifra, M., Salari, V., Simon, C., Tuszynski, J. A.   +4 more
core   +1 more source

Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. [PDF]

, 1992
Kinesin and dynein are motor proteins that move in opposite directions along microtubules. In this study, we examine the consequences of having kinesin and dynein (ciliary outer arm or cytoplasmic) bound to glass surfaces interacting with the same ...
Brown, D, Malik, F, Vale, RD
core   +2 more sources