Results 71 to 80 of about 453,492 (382)

Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories

Frontiers in Molecular Neuroscience, 2021
The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and ...
Camille Cuveillier, Benoit Boulan, Charlotte Ravanello, Eric Denarier, Jean-Christophe Deloulme, Sylvie Gory-Fauré, Christian Delphin, Christophe Bosc, Isabelle Arnal, Annie Andrieux   +9 more
doaj   +1 more source

Modeling oscillatory Microtubule--Polymerization [PDF]

, 2002
Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of microtubules.
A. Desai, A. Hyman, A. Marx, A. Suzuki, A.C. Newell, A.L. Hitt, B. Houchmandzadeh, C.M. Coppin, D. Sept, D.K. Fygenson, E. Jobs, E. Mandelkow, E.-M. Mandelkow, E.M. Mandelkow, F. Pirolet, F.J. Nedelec, G. Lange, G.J. Vroege, H. Flyvbjerg, H. Oberman, I. Aranson, J. Käs, J. Tabony, J. Tabony, J. Tabony, J. Tabony, L. Onsager, M. Dogterom, M.C. Cross, M.F. Carlier, N. Caudron, O. Valiron, R. Furukawa, R. Melki, R. Wade, T. Surrey, T.J. Mitchison, T.J. Mitchison, W. Schöpf, Y. Chen   +39 more
core   +2 more sources

Taxol®: The First Microtubule Stabilizing Agent

International Journal of Molecular Sciences, 2017
Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent described in the literature. This short review of the mechanism of action of Taxol® emphasizes the research done in the Horwitz’ laboratory.
C. Yang, S. Horwitz
semanticscholar   +1 more source

Microtubules and motors [PDF]

Molecular Biology of the Cell, 2012
New tools and approaches are providing exciting new insights into the structure and function of motors and microtubules and their contributions to cell migration, mitosis, and neuronal function. Janel Titus, from the Wadsworth laboratory (University of Massachusetts, Amherst), discussed the regulation of the plus end–directed mitotic motor Eg5 by ...
Jonathon Howard, Pat Wadsworth
openaire   +1 more source

Microtubule self-repair

Current Opinion in Cell Biology, 2021
The stochastic switching between microtubule growth and shrinkage is a fascinating and unique process in the regulation of the cytoskeleton. To understand it, almost all attention has been focused on the microtubule ends. However, recent research has revived the idea that tubulin dimers can also be exchanged in protofilaments along the microtubule ...
Manuel Théry, Manuel Théry, Laurent Blanchoin, Laurent Blanchoin   +3 more
openaire   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

eLife, 2013
Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-
Marvin E Tanenbaum, Ronald D Vale, Richard J McKenney   +2 more
doaj   +1 more source

Length control of microtubules by depolymerizing motor proteins [PDF]

, 2008
In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the ...
B. S. Govindan, D. Chowdhury, Hunter A. W., M. Gopalakrishnan   +3 more
core   +2 more sources

Competition between microtubule-associated proteins directs motor transport

bioRxiv, 2017
Within cells, motor and non-motor microtubule-associated proteins (MAPs) simultaneously converge on the microtubule. How the binding activities of non-motor MAPs are coordinated and how they contribute to the balance and distribution of motor transport ...
Brigette Y. Monroy, Danielle L. Sawyer, Bryce E. Ackermann, Melissa M. Borden, Tracy C. Tan, K. Ori-McKenney   +5 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source