Results 71 to 80 of about 341,120 (249)
Molecular Mechanisms for Microtubule Length Regulation by Kinesin-8 and XMAP215 Proteins
The cytoskeleton is regulated by a plethora of enzymes that influence the stability and dynamics of cytoskeletal filaments. Molecular motors of the kinesin-8 protein family depolymerise microtubules in a length-dependent manner, and experimental and ...
Frey, Erwin+2 more
core +1 more source
Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen+67 more
core +4 more sources
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes.
Wen-Tsan Chang+10 more
doaj +1 more source
Spatial and Temporal Sensing Limits of Microtubule Polarization in Neuronal Growth Cones by Intracellular Gradients and Forces [PDF]
Neuronal growth cones are the most sensitive amongst eukaryotic cells in responding to directional chemical cues. Although a dynamic microtubule cytoskeleton has been shown to be essential for growth cone turning, the precise nature of coupling of the ...
Athale, Chaitanya A., Mahajan, Saurabh
core +2 more sources
A model for the orientational ordering of the plant microtubule cortical array [PDF]
The plant microtubule cortical array is a striking feature of all growing plant cells. It consists of a more or less homogeneously distributed array of highly aligned microtubules connected to the inner side of the plasma membrane and oriented transversely to the cell growth axis.
arxiv +1 more source
DNA topology dictates strength and flocculation in DNA-microtubule composites [PDF]
Polymer composites are ubiquitous in biology and industry alike, owing to their emergent desirable mechanical properties not attainable in single-species systems. At the same time, polymer topology has been shown to play a key role in tuning the rheology of polymeric fluids.
arxiv
Prime movers : mechanochemistry of mitotic kinesins [PDF]
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy+184 more
core +1 more source
The microtubule cytoskeleton is a primary organizer of viral infections for delivering virus particles to their sites of replication, establishing and maintaining subcellular compartments where distinct steps of viral morphogenesis take place, and ...
Helena Lynn+3 more
doaj +1 more source
A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Anilkumar+50 more
core +4 more sources
Dynein-driven self-organization of microtubules: An entropy- and network-based analysis [PDF]
Microtubules self-organize to form part of the cellular cytoskeleton. They give cells their shape and play a crucial role in cell division and intracellular transport. Strikingly, microtubules driven by motor proteins reorganize into stable mitotic/meiotic spindles with high spatial and temporal precision during successive cell division cycles ...
arxiv