Results 71 to 80 of about 407,687 (331)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]

, 2018
Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le, Tymanskyj, Stephen R., Verhey, Kristen J., Yang, Benjamin   +3 more
core   +1 more source

The Mating-specific Gα Interacts with a Kinesin-14 and Regulates Pheromone-induced Nuclear Migration in Budding Yeast [PDF]

, 2009
As a budding yeast cell elongates toward its mating partner, cytoplasmic microtubules connect the nucleus to the cell cortex at the growth tip.
Cooper, John A, Draper, Edward, Durbrovskyi, Oleksii, Metodiev, Metodi V, Nelson, Scott A, Stone, David E, Zaichick, Sofia V   +6 more
core   +4 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules [PDF]

, 2007
Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions.
Georgiev, Danko, Glazebrook, James, Papaioanou, Stelios   +2 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport [PDF]

, 2010
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells.
A Peaucelle, A. C Newell, A. J Fleming, A. R Paredez, A. R Paredez, C Lloyd, Carolyn Ohno, D Reinhardt, D Reinhardt, D. D Fisher, E. J Chapman, E. M Bayer, Elliot M. Meyerowitz, F Corson, F. A Ditengou, G. J Mitchison, G. V Reddy, H Jonsson, Henrik Jönsson, J Craft, J Friml, J Marc, J Petrasek, J. A Raven, Jan Traas, K Okada, M. G Heisler, Magalie Uyttewaal, Marcus G. Heisler, N Geldner, N. C Shaner, O Grandjean, O Hamant, Olivier Hamant, Ottoline Leyser, P Sahlin, P. B de Reuille, P. H Rubery, Pawel Krupinski, R Gutierrez, R Himmelspach, R. E Peterson, R. E Williamson, R. S Smith, S Douady, S Sakaguchi, W. R Scheible, Y Boutte, Y Cheng   +48 more
core   +6 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The human cytoplasmic dynein interactome reveals novel activators of motility

eLife, 2017
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson   +8 more
doaj   +1 more source

PET Imaging of [¹¹C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains

Molecules, 2020
Dysregulation of microtubules is commonly associated with several psychiatric and neurological disorders, including addiction and Alzheimer’s disease.
Naresh Damuka, Paul W. Czoty, Ashley T. Davis, Michael A. Nader, Susan H. Nader, Suzanne Craft, Shannon L. Macauley, Lindsey K. Galbo, Phillip M. Epperly, Christopher T. Whitlow, April T. Davenport, Thomas J. Martin, James B. Daunais, Akiva Mintz, Kiran Kumar Solingapuram Sai   +14 more
doaj   +1 more source