Results 81 to 90 of about 407,687 (331)

Diffusion of myosin V on microtubules [PDF]

, 2011
Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma, Schliwa, Manfred, Voith von Voithenberg, Lena, Zimmermann, Dennis, Ökten, Zeynep   +4 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

H+- and Na+- elicited rapid changes of the microtubule cytoskeleton in the biflagellated green alga Chlamydomonas

eLife, 2017
Although microtubules are known for dynamic instability, the dynamicity is considered to be tightly controlled to support a variety of cellular processes.
Yi Liu, Mike Visetsouk, Michelle Mynlieff, Hongmin Qin, Karl F Lechtreck, Pinfen Yang   +5 more
doaj   +1 more source

Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Microtubule dynamics are crucial for multiple cell functions, and cancer cells are particularly sensitive to microtubule-modulating agents. Here, we describe the design and synthesis of a series of (Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N ...
Xiang Zhou, Jiamin Liu, Jiao Meng, Yihong Fu, Zhibin Wu, Guiping Ouyang, Zhenchao Wang   +6 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

eLife, 2016
The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration.
Benjamin P Bouchet, Rosemarie E Gough, York-Christoph Ammon, Dieudonnée van de Willige, Harm Post, Guillaume Jacquemet, AF Maarten Altelaar, Albert JR Heck, Benjamin T Goult, Anna Akhmanova   +9 more
doaj   +1 more source

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Micropterus salmoides rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner [PDF]

, 2023
Jianfei Lu, Sheng Luo, Hao Tang, Jiahui Liang, Yifan Zhao, Yang Hu, Guan‐Jun Yang, Jiong Chen   +7 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Reconstitution of dynein transport to the microtubule plus end by kinesin

eLife, 2014
Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Anthony J Roberts, Brian S Goodman, Samara L Reck-Peterson   +2 more
doaj   +1 more source