Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark+11 more
core +2 more sources
Random intermittent search and the tug-of-war model of motor-driven transport [PDF]
We formulate the tug-of-war model of microtubule cargo transport by multiple molecular motors as an intermittent random search for a hidden target. A motor-complex consisting of multiple molecular motors with opposing directional preference is modeled ...
Bressloff, P. C., Newby, Jay
core +2 more sources
Nuclear-localized subtype of end-binding 1 protein regulates spindle organization in Arabidopsis [PDF]
End-binding 1 (EB1) proteins are evolutionarily conserved plus-end-tracking proteins that localize to growing microtubule plus ends where they regulate microtubule dynamics and interactions with intracellular targets.
Abe, Tatsuya+5 more
core +2 more sources
Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela+5 more
doaj +1 more source
Microtubule‐Associated‐Protein MAP1 is not Implicated in the Polymerization of Microtubules [PDF]
Addition of DNA to microtubule protein solutions results in a decrease of the amount of the high‐molecular‐weight microtubule‐associated proteins (MAP1 and MAP2) available for polymerization. Complete removal of MAP1 from microtubules requires lower concentrations of DNA compared to MAP2.
Villasante, Alfredo+3 more
openaire +4 more sources
CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
doaj +1 more source
Identification of microtubule-associated proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo. [PDF]
We have developed affinity chromatography methods for the isolation of microtubule-associated proteins (MAPs) from soluble cytoplasmic extracts and have used them to analyze the cytoskeleton of the early Drosophila embryo.
Alberts, BM, Field, CM, Kellogg, DR
core
Polymorphic Dynamics of Microtubules [PDF]
Starting from the hypothesis that the tubulin dimer is a conformationally bistable molecule - fluctuating between a curved and a straight configuration at room temperature - we develop a model for polymorphic dynamics of the microtubule lattice. We show that tubulin bistability consistently explains unusual dynamic fluctuations, the apparent length ...
arxiv
Motor protein transport along inhomogeneous microtubules [PDF]
Many cellular processes rely on the cell's ability to transport material to and from the nucleus. Networks consisting of many microtubules and actin filaments are key to this transport. Recently, the inhibition of intracellular transport has been implicated in neurodegenerative diseases such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS)
arxiv
N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury
Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-acyl side chain.
Christian Witzel+3 more
doaj +1 more source