Results 181 to 190 of about 21,311 (203)

Effects of α-tubulin acetylation on microtubule structure and stability [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Acetylation of K40 in α-tubulin is the sole posttranslational modification to mark the luminal surface of microtubules. It is still controversial whether its relationship with microtubule stabilization is correlative or causative. We have obtained high-resolution cryo-electron microscopy (cryo-EM) reconstructions of pure samples of αTAT1-acetylated and
Lisa Eshun-Wilson, Didier Portran, Maxence V Nachury   +2 more
exaly   +7 more sources

Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase [PDF]

Cell, 2014
Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen. It marks stable microtubules and is required for polarity establishment and directional migration. Here, we elucidate the mechanistic underpinnings for TAT activity and its preference for microtubules with slow ...
Agnieszka Szyk, Alexandra M Deaconescu, Nikolaus Grigorieff   +2 more
exaly   +4 more sources

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Microtubule acetylation: A reading key to neural physiology and degeneration

Neuroscience Letters, 2021
Neurons are the perfect example of cells where microtubules are essential to achieve an extraordinary degree of morphological and functional complexity. Different tubulin isoforms and associated post-translational modifications are the basis to establish the diversity in biochemical and biophysical properties of microtubules including their stability ...
Graziella Cappelletti, Alessandra M Calogero, Chiara Rolando   +2 more
exaly   +3 more sources

Microtubule acetylation regulates dynamics of KIF1C-powered vesicles and contact of microtubule plus ends with podosomes

European Journal of Cell Biology, 2014
Microtubule dynamics are important for a variety of key cellular functions such as intracellular trafficking, adjustment of the cell surface proteome, or adhesion structure turnover. In the current study, we investigate the effects of altered microtubule acetylation levels on the subcellular distribution of kinesins and actin cytoskeletal architecture ...
Stefan Linder
exaly   +3 more sources

Acetylation keeps microtubules strong

Science, 2017
Cytoskeleton Cells need microtubules for intracellular transport and to avoid being crushed. On investigating microtubule breakage in live fibroblasts, Xu et al. found that if they were not acetylated, long-lived microtubules underwent frequent rupture after buckling.
openaire   +2 more sources

SIRT2 Mediated Microtubule Acetylation in Osteogenic Differentiation.

The Chinese journal of dental research
To assess the role of microtubule acetylation in the transportation of amorphous calcium phosphate (ACP)-containing vesicles that mediate the osteogenic differentiation process of rat bone mesenchymal stem cells (BMSCs).Rat BMSCs were cultured and transfected with sirtuin 2 (SIRT2) overexpression plasmids for an in vitro model.
Xin Ru, Zhou, Can, Zhang, Chen Rong, Xu, Xin Er, Tan, Qian Qian, Han, Xi, Yang, Tian Yu, Sun, Long Quan, Shao, Jia, Liu   +8 more
openaire   +2 more sources

Composite microtubules of the axon: quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules

Journal of Cell Science, 1993
ABSTRACT We have shown previously, using immunoelectron microscopy, that axonal microtubules (MTs) are composite, consisting of distinct domains that differ in their content of tyrosinated α-tubulin (tyr-tubulin). Here, we extend these studies using a novel preparation that permits visualization of individual axonal MTs over distances of
A, Brown, Y, Li, T, Slaughter, M M, Black   +3 more
openaire   +2 more sources

Colocalisation of acetylated microtubules, glial filaments, and mitochondria in astrocytes in vitro

Cell Motility, 1988
AbstractWe have recently shown that acetylated α‐tubulin containing microtubules (acety1‐MTs; labeled by antibody 6‐11B‐1) constitute a cold‐stable subset of the microtubule network of nonneuronal cells in rat primary forebrain cultures [Cambray‐Deakin and Burgoyne: Cell Motil. 8(3):284–291, 1987b].
M A, Cambray-Deakin, S J, Robson, R D, Burgoyne   +2 more
openaire   +2 more sources

Establishment of a stable, acetylated microtubule bundle during neuronal commitment

Cell Motility, 1989
AbstractTwo posttranslational modifications of alpha‐tubulin, acetylation and detyrosination, are associated with stable microtubule (MT) populations, including those of neuronal processes. We have used a pluripotent embryonal carcinoma cell line, P19, to investigate changes in MT isotype and stability found in MT arrays during neurogenesis.
M M, Falconer, U, Vielkind, D L, Brown
openaire   +2 more sources

Acetylated α-tubuin in the pollen tube microtubules

Cell Biology International Reports, 1992
Three monoclonal alpha-tubulin antibodies YL 1/2 (Kilmartin et al., 1982), 6-11B-1 (Piperno and Fuller, 1985) and DM1A (Blose et al., 1984) were used in indirect immunofluorescence (IIF) microscopy of the microtubule (MT) cytoskeleton in tobacco (Nicotiana tabacum) pollen tubes.
openaire   +1 more source