Results 151 to 160 of about 242,523 (302)

Anillin directly crosslinks microtubules with actin filaments. [PDF]

open access: yesEMBO J
Bareja I   +8 more
europepmc   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

open access: yesAdvanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang   +21 more
wiley   +1 more source

The mechanism of microtubule assembly in vitro [PDF]

open access: bronze, 1974
Marc W. Kirschner, Robley C. Williams
openalex   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

open access: yesAdvanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang   +20 more
wiley   +1 more source

The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules. [PDF]

open access: yesNat Commun
Gopal D   +10 more
europepmc   +1 more source

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