Results 171 to 180 of about 148,484 (307)

Declining centromere strength compromises meiotic chromosome segregation in aging oocytes. [PDF]

J Cell Biol
Lemonnier T, Dumont M, Leem J, Khan A, Yazdkhasti H, Zimyanin V, Khutsaidze A, Redemann S, Fachinetti D, Mogessie B.   +9 more
europepmc   +1 more source

Elastic vibrations in seamless microtubules

Parameters characterizing elastic properties of microtubules, measured in several recent experiments, reflect an anisotropic character. We describe the microscopic dynamical properties of microtubules using a discrete model based on an appropriate ...

core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons. [PDF]

Elife
Beaudet D, Berger CL, Hendricks AG.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

VvDLK negatively regulates cold tolerance by interacting with Vv14-3-3A in grapevine. [PDF]

Plant Physiol
Wu J, Shi W, Luo S, Magnus Armlich L, Wu Y, Liu Q, Chen X, Eliseev R, Karsten Kretzler N, Kumar Halavath S, Guan P, Nick P.   +11 more
europepmc   +1 more source

Stable GDP-tubulin islands rescue dynamic microtubules

International audienceMicrotubules are dynamic polymers that interconvert between phases of growth and shrinkage, yet they provide structural stability to cells.
Pinson, Benoît, Delphin, Christian, Nawabi, Homaira, Couté, Yohann, Delaroche, Julie, Gory-Fauré, Sylvie, Andrieux, Annie, de Andrade, Manon, Serre, Laurence, Carcel, Marion, Bagdadi, Nassiba, Stoppin-Mellet, Virginie, Arnal, Isabelle, Vérin, Claire, Wu, Juliette   +14 more
core   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Integrating cortical microtubules into plant gravity signaling: dynamics, tubulin phosphorylation, and growth regulation. [PDF]

Front Plant Sci
Islam MS, Wyatt SE.
europepmc   +1 more source