Results 231 to 240 of about 242,523 (302)

The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells. [PDF]

Sci Rep
Altieri L, Damizia M, Rovella P, Costanzo V, Mancini M, Di Micco P, Marzi M, Trisciuoglio D, Morea V, Lavia P.   +9 more
europepmc   +1 more source

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

BioEssays, EarlyView.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

LRRK2 interactions with microtubules are independent of LRRK2-mediated Rab phosphorylation. [PDF]

EMBO Rep
Malankhanova T, Liu Z, Xu E, Bryant N, Sung KW, Li H, Strader S, West AB.   +7 more
europepmc   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, EarlyView.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source

EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation. [PDF]

J Biol Chem
Marasi V, Adib R, O'Regan L, Straatman KR, Prigent SA, Fry AM.   +5 more
europepmc   +1 more source

Conformational Rearrangement of Fission DSPs

BioEssays, EarlyView.
Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Anelise N. Hutson, Kristy Rochon, Jason A. Mears   +2 more
wiley   +1 more source

Discovery of unique mitotic mechanisms in <i>Paradiplonema papillatum</i>. [PDF]

Open Biol
Akiyoshi B, Faktorová D, Lukeš J.
europepmc   +1 more source

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

The post-translational modification of NuMA in cancer cells is a new target for cancer eradication. [PDF]

Cell Death Dis
Cohen-Armon M.
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source