Results 71 to 80 of about 336,224 (375)

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes. [PDF]

PLoS Biology, 2008
Cytokinesis is powered by the contraction of actomyosin filaments within the newly assembled contractile ring. Microtubules are a spindle component that is essential for the induction of cytokinesis. This induction could use central spindle and/or astral
Wei Chen, Margit Foss, Kuo-Fu Tseng, Dahong Zhang   +3 more
doaj   +1 more source

Collision induced spatial organization of microtubules

, 2006
The dynamic behavior of microtubules in solution can be strongly modified by interactions with walls or other structures. We examine here a microtubule growth model where the increase in size of the plus-end is perturbed by collisions with other ...
Bassetti, Bastiaens, Baulin, Baulin, Bray, Canaday, Carlos M. Marques, Caudron, Cortes, Desai, Deymier, Dhonukshe, Dixit, Dogterom, Dogterom, Fabrice Thalmann, Gadde, Glade, Glade, Glade, Himmelspach, Himmelspach, Howard, Hyman, Janosi, Karsenti, Krebs, Lloyd, Maly, Maly, Mandelkow, Marx, Melki, Murata, Onsager, Portet, Robert, Sept, Tabony, Tabony, Tabony, Tuszynski, van Bruaene, Vladimir A. Baulin, Vorobjev, Vos, Wymer   +46 more
core   +5 more sources

Diffusion of myosin V on microtubules [PDF]

, 2011
Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma, Schliwa, Manfred, Voith von Voithenberg, Lena, Zimmermann, Dennis, Ökten, Zeynep   +4 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Dissecting the molecular mechanism underlying the intimate relationship between cellulose microfibrils and cortical microtubules

Frontiers in Plant Science, 2014
A central question in plant cell development is how the cell wall determines directional cell expansion and therefore the final shape of the cell. As the major load-bearing component of the cell wall, cellulose microfibrils are laid down transversely to ...
Lei eLei, Shundai eLi, Logan eBashline, Ying eGu   +3 more
doaj   +1 more source

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules. [PDF]

PLoS ONE, 2012
In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation.
Jennine M Dawicki-McKenna, Yale E Goldman, E Michael Ostap   +2 more
doaj   +1 more source

Elastic properties of grafted microtubules [PDF]

, 2005
We use single-particle tracking to study the elastic properties of single microtubules grafted to a substrate. Thermal fluctuations of the free microtubule's end are recorded, in order to measure position distribution functions from which we calculate ...
A. Jonas, Chretien, Chr  tien, Chr  tien, Chr  tien, de Pablo, E. Frey, E.-L. Florin, F. Pampaloni, Felgner, G. Lattanzi, Gittes, Humphrey, Hunyadi, Janson, J  nosi, Kasas, Kasas, Keskin, Kis, Kroy, Kurachi, Le Goff, Mickey, Needleman, Nogales, N  d  lec, Schaap, Sept, Speidel, T. Surrey, VanBuren, Venier, Wilhelm, Wong   +34 more
core   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source