Results 71 to 80 of about 249,538 (351)

Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes. [PDF]

PLoS Biology, 2008
Cytokinesis is powered by the contraction of actomyosin filaments within the newly assembled contractile ring. Microtubules are a spindle component that is essential for the induction of cytokinesis. This induction could use central spindle and/or astral
Wei Chen, Margit Foss, Kuo-Fu Tseng, Dahong Zhang   +3 more
doaj   +1 more source

Modeling oscillatory Microtubule--Polymerization [PDF]

, 2002
Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of microtubules.
A. Desai, A. Hyman, A. Marx, A. Suzuki, A.C. Newell, A.L. Hitt, B. Houchmandzadeh, C.M. Coppin, D. Sept, D.K. Fygenson, E. Jobs, E. Mandelkow, E.-M. Mandelkow, E.M. Mandelkow, F. Pirolet, F.J. Nedelec, G. Lange, G.J. Vroege, H. Flyvbjerg, H. Oberman, I. Aranson, J. Käs, J. Tabony, J. Tabony, J. Tabony, J. Tabony, L. Onsager, M. Dogterom, M.C. Cross, M.F. Carlier, N. Caudron, O. Valiron, R. Furukawa, R. Melki, R. Wade, T. Surrey, T.J. Mitchison, T.J. Mitchison, W. Schöpf, Y. Chen   +39 more
core   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

Cell Reports, 2017
Axonal microtubules are predominantly organized into a plus-end-out pattern. Here, we tested both experimentally and with computational modeling whether a motor-based polarity-sorting mechanism can explain this microtubule pattern.
Anand N. Rao, Ankita Patil, Mark M. Black, Erin M. Craig, Kenneth A. Myers, Howard T. Yeung, Peter W. Baas   +6 more
doaj   +1 more source

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules. [PDF]

PLoS ONE, 2012
In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation.
Jennine M Dawicki-McKenna, Yale E Goldman, E Michael Ostap   +2 more
doaj   +1 more source

Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells [PDF]

, 2009
© The Authors, 2009 . This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 186 (2009): 727-738, doi:10.1083/jcb ...
Griffis, Eric R., Spudich, James A., Vale, Ronald D.   +2 more
core   +5 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Microtubule heterogeneity of Ornithogalum umbellatum ovary epidermal cells: non-stable cortical microtubules and stable lipotubuloid microtubules

Folia Histochemica et Cytobiologica, 2011
Lipotubuloids, structures containing lipid bodies and microtubules, are described in ovary epidermalcells of Ornithogalum umbellatum. Microtubules of lipotubuloids can be fixed in electron microscope fixativecontaining only buffered OsO4 or in ...
Maria Kwiatkowska, Dariusz Stępiński, Justyna T. Polit, Katarzyna Popłońska, Agnieszka Wojtczak   +4 more
doaj  

Unbiased pattern analysis reveals highly diverse responses of cytoskeletal systems to cyclic straining.

PLoS ONE, 2019
In mammalian cells, actin, microtubules, and various types of cytoplasmic intermediate filaments respond to external stretching. Here, we investigated the underlying processes in endothelial cells plated on soft substrates from silicone elastomer.
Ronald Springer, Alexander Zielinski, Catharina Pleschka, Bernd Hoffmann, Rudolf Merkel   +4 more
doaj   +1 more source

Effect of 2-H and 18-O water isotopes in kinesin-1 gliding assay [PDF]

, 2012
We show here the effects of heavy-hydrogen water (^2^H~2~O) and heavy-oxygen water (H~2~^18^O) on the gliding speed of microtubules on kinesin-1 coated surfaces.
Andy Maloney, Lawrence J. Herskowitz, Steven J. Koch   +2 more
core   +1 more source