Results 51 to 60 of about 148,484 (307)

Studies on the interaction between "Tobacco Mosaic Virus" movement protein and microtubules [PDF]

, 2003
During the invasion of a susceptible host, Tobacco mosaic virus (TMV) transports its RNA genome from sites of viral synthesis into neighbouring cells, thus potentiating the spread of infection.
Ashby, Jamie A.
core   +1 more source

Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation

New Journal of Physics, 2018
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye, Olivia Stiehl, Peter J Foster, Michael J Shelley, Daniel J Needleman, Sebastian Fürthauer   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ionizing Radiation Effects on Hs 578Bst Microtubules

Frontiers in Physics, 2020
Microtubules are one of the three components of the cell cytoskeleton. They are hollow wires, with a diameter of about 25 nm, formed by 13 laterally associated protofilaments composed by dimers of α and β-tubulin.
L. Bruni, M. Manghi, M. Manghi, E. Gioscio, E. Gioscio, V. Caorsi, F. M. Rizzi, S. Croci, S. Croci   +8 more
doaj   +1 more source

Inhibition of cell expansion enhances cortical microtubule stability in the root apex of Arabidopsis thaliana

Journal of Biological Research - Thessaloniki, 2021
Background Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana. While the regulation of cell wall properties by cortical microtubules is well studied, the data on the ...
Veronica Giourieva, Emmanuel Panteris
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Evidence for an interaction of paracingulin with microtubules

microPublication Biology
The mechanisms that anchor microtubules to epithelial junctions are poorly understood. Here we show that recombinant purified paracingulin (CGNL1, JACOP), a cytoplasmic junctional protein, decorates microtubules by negative staining electron microscopy ...
Arielle Flinois, Annick Mutero-Maeda, Sylvie Montessuit, Sandra Citi   +3 more
doaj   +1 more source

Microtubules in Polyomavirus Infection

Viruses, 2020
Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection.
Lenka Horníková, Kateřina Bruštíková, Jitka Forstová   +2 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source