Results 41 to 50 of about 108,812 (267)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Microtubule heterogeneity of Ornithogalum umbellatum ovary epidermal cells: non-stable cortical microtubules and stable lipotubuloid microtubules

Folia Histochemica et Cytobiologica, 2011
Lipotubuloids, structures containing lipid bodies and microtubules, are described in ovary epidermalcells of Ornithogalum umbellatum. Microtubules of lipotubuloids can be fixed in electron microscope fixativecontaining only buffered OsO4 or in ...
Maria Kwiatkowska, Dariusz Stępiński, Justyna T. Polit, Katarzyna Popłońska, Agnieszka Wojtczak   +4 more
doaj  

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

Cell Reports, 2017
Axonal microtubules are predominantly organized into a plus-end-out pattern. Here, we tested both experimentally and with computational modeling whether a motor-based polarity-sorting mechanism can explain this microtubule pattern.
Anand N. Rao, Ankita Patil, Mark M. Black, Erin M. Craig, Kenneth A. Myers, Howard T. Yeung, Peter W. Baas   +6 more
doaj   +1 more source

Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules

Acta Biochimica et Biophysica Sinica, 2023
Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells. In vertebrates, both α- and β-tubulins have multiple isotypes encoded by different genes, which are intrinsic factors in
Diao Lei, Zheng Wei, Zhao Qiaoyu, Liu Mingyi, Fu Zhenglin, Zhang Xu, Bao Lan, Cong Yao   +7 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Does usnic acid affect microtubules in human cancer cells?

Brazilian Journal of Biology
Usnic acid, a lichen metabolite, is known to exert antimitotic and antiproliferative activities against normal and malignant human cells. Many chemotherapy agents exert their activities by blocking cell cycle progression, inducing cell death through ...
MA. O'Neill, M. Mayer, KE. Murray, HML. Rolim-Santos, NS. Santos-Magalhães, AM. Thompson, VCL. Appleyard   +6 more
doaj   +1 more source

Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer

Biomedicines, 2020
Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However, as anticancer drugs targeting microtubules have side effects, including the death of normal cells, it is necessary to ...
Ahreum Kwon, Gwi Bin Lee, Taein Park, Jung Hoon Lee, Panseon Ko, Eunae You, Jin Hee Ahn, Soo Hyun Eom, Sangmyung Rhee, Woo Keun Song   +9 more
doaj   +1 more source

Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics

Acta Protozoologica, 2021
Assays of protein contained in water-soluble fraction of encysting cells Colpoda cucullus Nag-1 by two-dimensional electrophoresis (2-D PAGE) and mass spectrometry (MS) revealed that the amount of β ...
Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Shiho Kikuchi, Yuto Shimada, Rikiya Nakamura, Mikihiko Arikawa, Seiji Miyata, Eiji Kinoshita, Futoshi Suizu, Tatsuomi Matsuoka   +10 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes. [PDF]

PLoS Biology, 2008
Cytokinesis is powered by the contraction of actomyosin filaments within the newly assembled contractile ring. Microtubules are a spindle component that is essential for the induction of cytokinesis. This induction could use central spindle and/or astral
Wei Chen, Margit Foss, Kuo-Fu Tseng, Dahong Zhang   +3 more
doaj   +1 more source