Results 71 to 80 of about 148,484 (307)

Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules

Acta Biochimica et Biophysica Sinica, 2023
Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells. In vertebrates, both α- and β-tubulins have multiple isotypes encoded by different genes, which are intrinsic factors in
Diao Lei, Zheng Wei, Zhao Qiaoyu, Liu Mingyi, Fu Zhenglin, Zhang Xu, Bao Lan, Cong Yao   +7 more
doaj   +1 more source

Cell proliferation, cell shape, and microtubule and cellulose microfibril organization of tobacco BY-2 cells are not altered by exposure to near weightlessness in space [PDF]

, 2009
The microtubule cytoskeleton and the cell wall both play key roles in plant cell growth and division, determining the plant’s final stature. At near weightlessness, tubulin polymerizes into microtubules in vitro, but these microtubules do not self ...
Emons, A.M.C., Jan W. Vos, Emons, A.M.C. (Anne Mie), Anne Mie C. Emons, Kieft, H., Sieberer, B., Vos, J.W., Franssen-Verheijen, M.A.W., Tiny Franssen-Verheijen, Björn J. Sieberer, Vos, J.W. (Jan), Sieberer, B.J., Henk Kieft, Franssen-Verheijen, T.   +13 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

eLife, 2018
Presence of multiple copies of the microtubule-binding NDC80 complex is an evolutionary conserved feature of kinetochores, points of attachment of chromosomes to spindle microtubules.
Vladimir A Volkov, Pim J Huis in 't Veld, Marileen Dogterom, Andrea Musacchio   +3 more
doaj   +1 more source

Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer

Biomedicines, 2020
Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However, as anticancer drugs targeting microtubules have side effects, including the death of normal cells, it is necessary to ...
Ahreum Kwon, Gwi Bin Lee, Taein Park, Jung Hoon Lee, Panseon Ko, Eunae You, Jin Hee Ahn, Soo Hyun Eom, Sangmyung Rhee, Woo Keun Song   +9 more
doaj   +1 more source

Microtubules in Plants [PDF]

The Arabidopsis Book, 2015
Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
openaire   +2 more sources

A molecular analysis of the microtubule associated protein MAP65-1 [PDF]

, 2006
Microtubules (MTs) play important roles in various cellular processes including cell division, organelle movement and the determination of cellular morphology. The dynamics and organization of microtubules are regulated by microtubule associated proteins
Hsin Yu, Chang
core  

Luminal particles within cellular microtubules. [PDF]

, 2006
The regulation of microtubule dynamics is attributed to microtubule-associated proteins that bind to the microtubule outer surface, but little is known about cellular components that may associate with the internal side of microtubules.
Kudryashev, M., Frank Bradke, Benoît Zuber, Baumeister, W, Gruska, Manuela, Baumeister, W., Frischknecht, F., Cyrklaff, M, Cyrklaff, Marek, Frischknecht, Friedrich, Dubochet, Jacques, Zuber, B, Cédric Bouchet-Marquis, Wolfgang Baumeister, Garvalov, B., Bradke, F., Frischknecht, F, Garvalov, Boyan K, Beck, M, Zuber, B., Bouchet-Marquis, C., Gruska, M, Leis, A., Kudryashev, M, Baumeister, Wolfgang, Leis, A, Dubochet, J., Beck, M., Manuela Gruska, Marek Cyrklaff, Garvalov, BK, Martin Beck, Bradke, Frank, Cyrklaff, M., Andrew Leis, Jacques Dubochet, Kudryashev, M. ; https://orcid.org/, Kudryashev, Mikhail, Gruska, M., Bradke, F, Mikhail Kudryashev, Bouchet-Marquis, C, Garvalov, B.K., Zuber, Benoît, Dubochet, J, Beck, Martin, Boyan K. Garvalov, Friedrich Frischknecht, Bouchet-Marquis, Cédric, Leis, Andrew, Garvalov, Boyan K.   +50 more
core   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source