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iPS Cell Differentiation into Brain Microvascular Endothelial Cells
2022The blood-brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers protection to the brain microenvironment from toxins or any fluctuations in the composition of the blood plasma via a layer of endothelial cells connected by tight junctions and supported by pericytes and ...
Angelica, Medina, Hengli, Tang
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Culturing endothelial cells of microvascular origin
Methods in Cell Science, 2000There is considerable divergence of opinion on the best methods for the isolation and in vitro culture of microvascular endothelium. Reports have either only described the isolation without mentioning culture conditions or have not fully defined the cell population being cultured.
F, Manconi, R, Markham, I S, Fraser
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Vitronectin decreases microvascular endothelial cell apoptosis
Journal of Cellular Physiology, 1998Angiogenesis after tissue injury occurs in a matrix environment consisting of fibrin, fibronectin, and vitronectin as the major extracellular matrix (ECM) constituents. ECM-integrin interactions is critical for angiogenesis and failure to bind a ligand to certain integrin receptors (alpha[v]beta3 or alpha[v]beta5) inhibits angiogenesis. The ligand that
F F, Isik +4 more
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Ca2+ homeostasis in brain microvascular endothelial cells
2021Blood brain barrier (BBB) is formed by the brain microvascular endothelial cells (BMVECs) lining the wall of brain capillaries. Its integrity is regulated by multiple mechanisms, including up/downregulation of tight junction proteins or adhesion molecules, altered Ca2+ homeostasis, remodeling of cytoskeleton, that are confined at the level of BMVECs ...
Roberta, Stoica +5 more
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Microvascular endothelial cell heterogeneity
Cell and Tissue Research, 2009Microvascular endothelial cells display a large degree of heterogeneity in function depending on their location in the vascular tree. The existence of organ-specific, microvascular-bed-specific, and even intravascular variations in endothelial cell gene expression emphasizes their high cell-to-cell variability, which is furthermore extremely adaptable ...
Langenkamp, Elise, Molema, Grietje
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Diversity in human placental microvascular endothelial cells and macrovascular endothelial cells
Cytokine, 2018Angiogenesis is fundamental to normal placental development, and aberrant angiogenesis contributes substantially to placental pathologies. Placental angiogenesis is a pivotal process that plays a key mechanistic role in the elaboration of the placental villous tree, which is mainly taken by human placental microvascular endothelial cells (HPMECs ...
Xiaojie, Huang +8 more
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Myometrial microvascular endothelial cells express oxytocin receptor
BJOG: An International Journal of Obstetrics & Gynaecology, 2003Objective 1. To establish whether microvascular endothelial cells from the human myometrium (MMECs) express oxytocin receptor, and to compare its expression levels relative to HUVECs. 2. To verify an up‐regulation of oxytocin receptor expression in MMECs as a result of vascular endothelial growth factor (VEGF), which had been found in a previous ...
G C, Weston, L, Cann, P A W, Rogers
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Homocysteine in Microvascular Endothelial Cell Barrier Permeability
Cell Biochemistry and Biophysics, 2005Redox stress activates the endothelium and upregulates matrix metalloproteinases (MMPs), which degrade the matrix and lead to blood-endothelial barrier leakage. Interestingly, elevated levels of plasma homocysteine (Hcy) are associated with vascular dementia, seizure, stroke, and Alzheimer disease. Hcy competes with the gamma-aminobutyric acid (GABA)-A/
Suresh C, Tyagi +2 more
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Proproliferative phenotype of pulmonary microvascular endothelial cells
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007Endothelial cells perform a number of important functions including release of vasodilators, control of the coagulation cascade, and restriction of solutes and fluid from the extravascular space. Regulation of fluid balance is of particular importance in the microcirculation of the lung where the loss of endothelial barrier function can lead to ...
Victor, Solodushko, Brian, Fouty
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