Results 61 to 70 of about 18,155 (253)

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

International Journal of Molecular Sciences, 2017
Microvesicle (MV) release from tumour cells influences drug retention, contributing to cancer drug resistance. Strategically regulating MV release may increase drug retention within cancer cells and allow for lower doses of chemotherapeutic drugs.
Uchini S. Kosgodage, R. P. Trindade, P. Thompson, J. Inal, S. Lange   +4 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Extracellular vesicles in multiple sclerosis: what are they telling us?

Frontiers in Cellular Neuroscience, 2014
Extracellular vesicles (EVs) are membrane-bound particles secreted by almost all cell types. They are classified depending on their biogenesis and size into exosomes and microvesicles or according to their cell origin.
Matías eSáenz-Cuesta, Matías eSáenz-Cuesta, Iñaki eOsorio-Querejeta, Iñaki eOsorio-Querejeta, David eOtaegui, David eOtaegui   +5 more
doaj   +1 more source

Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34+ Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Mesenchymal stem cells (MSCs) release hematopoietic cytokines, growth factors, and Microvesicles (MVs) supporting the hematopoietic stem cells (HSCs).
Sara Aqmasheh, Karim Shamsasenjan, Elham Khalaf Adeli, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Davod Pashoutan Sarvar, Hamzeh Timari   +6 more
doaj   +1 more source

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.

Blood, 2018
von Willebrand factor (VWF) is an adhesive ligand, and its activity is proteolytically regulated by the metalloprotease ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat 13).
Yingang Wu, Wei Liu, Yuan Zhou, Tristan Hilton, Zilong Zhao, W. Liu, Min Wang, Jason Yeon, Katie L. Houck, P. Thiagarajan, Fangyi Zhang, F. Shi, Xiaoping Wu, Min Li, Jing-fei Dong, Jian-ning Zhang   +15 more
semanticscholar   +1 more source

At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis

Advanced Healthcare Materials, EarlyView.
Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang, Chayla L. Reeves, Mehrnoosh Moghaddar, Kate E. Fox, Aaron Elbourne, Amy Gelmi   +5 more
wiley   +1 more source

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells In vitro

Frontiers in Cellular Neuroscience, 2021
Brain microvascular endothelial cells (BMECs) are a major component of the blood-brain barrier that maintains brain homeostasis. Preserving and restoring the normal biological functions of BMECs can reverse or reduce brain injury.
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju   +4 more
doaj   +1 more source

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Advancement of science, 2018
A novel metal–organic particle (MOP) based nanodrug formed by mild self‐assembly of chemotherapeutic drugs, including banoxantrone and doxorubicin, through Cu(II)‐mediated coordination effects, is reported.
Da Zhang, Ming Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, G. Liu, Huanghao Yang, Xiaolong Liu, Jingfeng Liu   +10 more
semanticscholar   +1 more source

Evaluation of Cell‐Extracellular Vesicle Interaction Using a Microfluidic Microsystem (CellExoChip)

Advanced Materials Technologies, EarlyView.
A new microfluidic platform, the CellExoChip, reveals how cancer cells interact with exosomes to influence metastasis. This device isolates cancer cells and tracks their uptake exosomes and secretion of their exosomes in response to other exosomes. Lung cancer cells are showed preferentially absorb and respond to their own exosomes—hinting at a hidden ...
Nna‐Emeka Onukwugha, Zeqi Niu, Abha Kumari, Scott Smith, Grace Li, Kruthi Srinivasa Raju, Joseph Marvar, Thomas Leekley, Shawn Fortna, Yoon‐Tae Kang, Sunitha Nagrath   +10 more
wiley   +1 more source

Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

Stem Cells Translational Medicine, 2016
Cell secretion is an important mechanism for stem cell‐based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells.
Ting Kang, Tia M Jones, Clayton Naddell, M. Bacanamwo, J. Calvert, W. Thompson, V. Bond, Y. E. Chen, Dong Liu   +8 more
semanticscholar   +1 more source