Results 101 to 110 of about 63,152 (354)

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Molecular Cancer, 2019
Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression.
X. Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, S. Ren, Jianhua Wang   +6 more
semanticscholar   +1 more source

Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress [PDF]

, 2017
Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited.
Chiesa, Scott T., González-Alonso, José, Kalsi, Kameljit K., Rakobowchuk, Mark, Trangmar, Steven J., Wilhelm, Eurico N.   +5 more
core   +5 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA ...
Miguel Tofiño-Vian, M. I. Guillén, M. D. Pérez del Caz, Antonio Silvestre, M. Alcaraz   +4 more
semanticscholar   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA. [PDF]

PLoS ONE, 2014
Intact RNA from exosomes/microvesicles (collectively referred to as microvesicles) has sparked much interest as potential biomarkers for the non-invasive analysis of disease.
Kevin C Miranda, Daniel T Bond, Joshua Z Levin, Xian Adiconis, Andrey Sivachenko, Carsten Russ, Dennis Brown, Chad Nusbaum, Leileata M Russo   +8 more
doaj   +1 more source

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression [PDF]

, 2016
BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon ...
A Bharthuar, A Delluc, A Falanga, A Rank, A Rank, AA Khorana, AA Khorana, Anthony Maraveyas, AS Wolberg, BA Lwaleed, C Ettelaie, C Ettelaie, C Hernández, C Sapet, Camille Ettelaie, E Camerer, E Campello, E Cocco, ES Breimo, F Doormaal van, F Langer, GW Tormoen, H Kothari, I Pabinger, J Ahamed, J Thaler, J Thaler, J Thaler, JA Bastarache, JE Geddings, JH Morrissey, John Greenman, K Haubold, KG Livak, L Hu, LV Rao, M Davila, Mary EW Collier, ME Collier, ME Collier, ME Collier, ME Collier, ME Tesselaar, ML Rand, N Satta, N Tavoosi, Naima E. Benelhaj, NS Key, P Bucciarelli, R Flaumenhaft, RI Kushak, S Butenas, SJ Compton, SK Dasgupta, Sophie Featherby, T Kawamoto, V Combes, W Ruf   +57 more
core   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Endothelial Microvesicles and Soluble Markers of Endothelial Injury in Critically Ill Newborns

Mediators of Inflammation, 2018
Neonatal systemic inflammatory response and multiple organ dysfunction syndrome are the main postnatal insults influencing mortality and morbidity. Critically ill newborns with high predicted mortality are supported by extracorporeal membrane oxygenation
Veronika Vítková, Martin Pánek, Petr Janec, Michaela Šibíková, Václav Vobruba, Martin Haluzík, Jan Živný, Jan Janota   +7 more
doaj   +1 more source