Results 71 to 80 of about 55,239 (279)

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Platelets and platelet-derived microvesicles: Phenotype, content, impact on endothelial cells

Медицинская иммунология
Blood platelets are circulating anuclear structures derived from megakaryocytes. Intercellular adhesion molecules, Toll-like receptors, chemokine and cytokine receptors are represented on their surface.
O. I. Stepanova, M. A. Pereviazkina, K. L. Markova, S. A. Selkov, D. I. Sokolov   +4 more
doaj   +1 more source

The role of microvesicles in tissue repair [PDF]

Organogenesis, 2011
Microvesicles (MVs) are released by almost all cells in resting and activated conditions. First described several years ago, it is only recently that their mechanisms of action are being elucidated, and their potential role in health and disease is drawing increasing attention.
Ciro, Tetta, Stefania, Bruno, Valentina, Fonsato, Maria Chiara, Deregibus, Giovanni, Camussi   +4 more
openaire   +2 more sources

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

Frontiers in Aging Neuroscience, 2021
IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau.
Janine Utz, Judith Berner, Luis Enrique Muñoz, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer   +9 more
doaj   +1 more source

Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress [PDF]

, 2017
Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited.
Chiesa, Scott T., González-Alonso, José, Kalsi, Kameljit K., Rakobowchuk, Mark, Trangmar, Steven J., Wilhelm, Eurico N.   +5 more
core   +5 more sources

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Microvesicles derived from leukocytes in the peripheral blood of patients with external genital endometriosis

Медицинская иммунология, 2022
Endometriosis is a chronic gynecological disease, which poses a serious problem in terms of diagnosis and treatment. Despite decades of research, there are no specific signs and symptoms and no blood tests to clinically confirm the diagnosis, which makes
M. I. Yarmolinskaya, E. I. Durneva, K. L. Markova, V. A. Mikhailova, S. A. Selkov, D. I. Sokolov   +5 more
doaj   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA. [PDF]

PLoS ONE, 2014
Intact RNA from exosomes/microvesicles (collectively referred to as microvesicles) has sparked much interest as potential biomarkers for the non-invasive analysis of disease.
Kevin C Miranda, Daniel T Bond, Joshua Z Levin, Xian Adiconis, Andrey Sivachenko, Carsten Russ, Dennis Brown, Chad Nusbaum, Leileata M Russo   +8 more
doaj   +1 more source

Acoustic Purification of Extracellular Microvesicles [PDF]

ACS Nano, 2015
Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in sample preparation, particularly when sample volumes are small.
Lee, Kyungheon, Shao, Huilin, Weissleder, Ralph, Lee, Hakho   +3 more
openaire   +3 more sources