Results 51 to 60 of about 53,120 (272)

Microvesicles and Cancer Associated Thrombosis [PDF]

Seminars in Thrombosis and Hemostasis, 2019
AbstractMicrovesicles (MVs) are small membrane enclosed structures released into the extracellular space by virtually all cell types. Their composition varies according to the cell origin and the stimulus which caused their formation. They harbor functional molecules and participate in intercellular communication.
Lacroix, Romaric, Vallier, Loris, Bonifay, Amandine, Simoncini, Stephanie, Mege, Diane, Aubert, Mathilde, Panicot-Dubois, Laurence, Dubois, Christophe, Dignat-George, Francoise   +8 more
openaire   +4 more sources

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]

, 2016
BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria, Carè, Alessandra, Coscia, Carolina, Errico, Maria Cristina, Felicetti, Federica, Feo, Alessandra De, Pagani, Elena, Pasquini, Luca, Pedini, Francesca, Puglisi, Rossella   +9 more
core   +5 more sources

Acoustic Purification of Extracellular Microvesicles [PDF]

ACS Nano, 2015
Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in sample preparation, particularly when sample volumes are small.
Lee, Kyungheon, Shao, Huilin, Weissleder, Ralph, Lee, Hakho   +3 more
openaire   +3 more sources

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

BMC Genomics, 2009
Background Various cancer cells, including those of colorectal cancer (CRC), release microvesicles (exosomes) into surrounding tissues and peripheral circulation.
Kim Yoon-Keun, Choi Dong-Sic, Kim Ji, Kim Jongmin, Rho Sangchul, Choi Eun-Jeong, Kim Hyunjung, Cho Ji-Hoon, Hong Bok, Hwang Daehee, Gho Yong   +10 more
doaj   +1 more source

Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation [PDF]

, 2015
We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial. In this study, TF-mediated mechanisms of induction of apoptosis were explored.
Collier, Mary E. W., ElKeeb, Azza M., Ettelaie, Camille, Maraveyas, Anthony   +3 more
core   +1 more source

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

The biology of extracellular microvesicles [PDF]

Traffic, 2018
The study of extracellular vesicles (EVs) is a rapidly evolving field, owing in large part to recent advances in the realization of their significant contributions to normal physiology and disease. Once discredited as cell debris, these membrane vesicles have now emerged as mediators of intercellular communication by interaction with target cells, drug
Alanna E. Sedgwick, Crislyn D'Souza‐Schorey   +1 more
openaire   +2 more sources

Platelet Microvesicles (Microparticles) in Cardiac Surgery [PDF]

Journal of Cardiothoracic and Vascular Anesthesia, 2016
SIGNIFICANT POSTOPERATIVE BLEEDING is a common risk of cardiac surgery, with approximately 3.5% of patients requiring surgical re-exploration.1 Re-exploration is associated with adverse outcomes, including infections, ischemia, and increased 30-day mortality.2 Similar adverse outcomes are related to erythrocyte transfusions associated with cardiac ...
Tempo, Jake, Englyst, Nicola A., Holloway, Judith A., Smith, David C.   +3 more
openaire   +4 more sources

Microguards and micromessengers of the genome [PDF]

, 2016
The regulation of gene expression is of fundamental importance to maintain organismal function and integrity and requires a multifaceted and highly ordered sequence of events.
A Bobrie, A Gioti, A Leiblich, A Lukasik, A Sharma, A Weiberg, AE Hall, AH Buck, B-C Yoo, C Braicu, C Fricke, D Green, D Haig, D Kim, DJ Sharkey, DM Pegtel, DP Bartel, E Marin-Gonzalez, E Tili, G Arnqvist, GL Hager, H Liu, H Valadi, H Zhou, J Lotvall, J Skog, JA Andres, JM Perkel, JR Chevillet, JS Parent, K Ohshima, K Sun, K Wang, L Corrigan, L Vojtech, LA McGraw, LA McGraw, LK Sirot, M Ghildiyal, M Greaves, M Mittelbrunn, MK Lawniczak, ML Squadrito, NS Barteneva, O Rechavi, P Cayirlioglu, P Kumar, P Xu, PB Medawar, PS Mitchell, S Mathivanan, S Sarker, S Weilner, S Wigby, S Wigby, T Chapman, T Chapman, T Chapman, T Chapman, T Chapman, T Dalmay, T Dalmay, T Kogure, TE Swingler, VN Kim, W Filipowicz, WX Chen, X Chen, Y Lee, Y Ouyang   +69 more
core   +1 more source

Microglial microvesicle secretion and intercellular signaling [PDF]

Frontiers in Physiology, 2012
Microvesicles (MVs) are released from almost all cell brain types into the microenvironment and are emerging as a novel way of cell-to-cell communication. This review focuses on MVs discharged by microglial cells, the brain resident myeloid cells, which comprise ∼10-12% of brain population.
Elena eTurola, Elena eTurola, Roberto eFurlan, Fabio eBianco, Michela eMatteoli, Michela eMatteoli, Michela eMatteoli, Claudia eVerderio, Claudia eVerderio   +8 more
openaire   +5 more sources