Results 1 to 10 of about 115,017 (336)

Midazolam and anaesthesia. [PDF]

British Journal of Clinical Pharmacology, 1983
By virtue of its physico‐chemical properties and its rapid biotransformation, midazolam is an important addition in certain areas in anaesthesia. Of particular importance are its good local tissue tolerance after intramuscular injection, the absence of venous irritation, and the rapid start of metabolism with good control of action.
W Kapp, M Gemperle
openaire   +5 more sources

Midazolam and diazepam for gastroscopy [PDF]

Anaesthesia, 1982
SummaryMidazolam 0.1 mg/kg was compared with diazepam 0.15 mg/kg intravenously in patients undergoing gastroscopy. The patients receiving midazolam were more sedated at the end of the procedure. The mean discharge times from the clinic for diazepam and midazolam patients were 85 and 102 minutes, respectively.
D. Al-Khudhairi, James G. Whitwam, R.F. Mccloy   +2 more
openaire   +4 more sources

Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies [PDF]

, 2020
Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited
Huebinger, Ryan M., Markul, Eddie, Pearlman, Kenneth S., Richards, Christopher T., Stein-Spencer, Leslee, Tataris, Katie L., Weber, Joseph M., Zaidi, Hashim Q.   +7 more
core   +1 more source

Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]

, 2010
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi, O\u27Dell, Kazuko A, Tokuda, Kazuhiro, Zorumski, Charles F   +3 more
core   +2 more sources

Opisthotonos and midazolam [PDF]

Journal of Pediatric Neurology, 2015
A 3-year-child, weighing 11.4 kgs, was admitted in the accident and emergency ward in status epilepticus of more than one hour duration. He was administered diazepam suppository followed by 3 doses of intravenous diazepam. When diazepam failed to control the status epilepticus a loading dose of phenytoin sodium 200 mg (18 mg per kg) was given. This too
Roshan Koul, Javed Hashim, Masod Ahmed
openaire   +2 more sources

The effect of transmucosal 0.2mg/kg Midazolam premedication on dental anxiety, anaesthetic induction and psychological morbidity in children undergoing general anaesthesia for tooth extraction [PDF]

, 2008
<b>Background:</b> The project aims were to evaluate the benefit of transmucosal Midazolam 0.2mg/kg pre-medication on anxiety, induction behaviour and psychological morbidity in children undergoing general anaesthesia (GA) extractions. <b&
A Keaney, A. J. Asbury, A. W. Bowman, AL Erlandsson, C Campbell, C Hogg, CK Schmidt, CM Bridgman, D Turkington, GM Humphris, H Buchanan, HM Parsons, HM Wong, J Elander, J Elander, J Rayner, JW Cole, K Millar, K Millar, K. Martin, K. Millar, LM Macpherson, M Rutter, M. T. Hosey, MA Lumley, MI Houpt, MT Hosey, MT Hosey, MT Hosey, NM Girdler, PA Lonnqvist, R Holn-Knudsen, R Seed, R. Welbury, S Calipel, T Horiuchi, T. Musiello, TA Bates, TK Howell, TN Johnson, V Carstairs, YP Ko   +41 more
core   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Intravenous conscious sedation in patients under 16 years of age. Fact or fiction? [PDF]

, 2003
Recently published guidelines on the use of conscious sedation in dentistry have published varying recommendations on the lower age limit for the use of intravenous conscious sedation.
J A Leitch, JG Meechan, M -T Hosey, N D Robb   +3 more
core   +1 more source

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]

, 2020
Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska, Devreese, Mathias, Dockx, Robrecht, Duchateau, Luc, Peremans, Kathelijne, Polis, Ingeborgh, Vlerick, Lise   +6 more
core   +1 more source

Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine [PDF]

, 2003
OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness. DESIGN: Pragmatic, randomised clinical trial. SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil. SUBJECTS:
Abreu, A.M., Adams, C.E., Borges, R.V.S., Coutinho, E.S.F., Dias, C.L., Ferreira, M.A.V., Gewandsznajder, M., Huf, G., Lange, W., Lugao, S.M., Mercadante, V.R.P., Pereira, A.J.C.R., Santos, M.P.C.P., Silva, F.J.F.   +13 more
core   +1 more source