Results 41 to 50 of about 119,569 (361)
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
JAI (Jurnal Anestesiologi Indonesia), 2010 Latar belakang: Premedikasi midazolam rutin diberikan pada anestesi spinal karena sangat bermanfaat untuk memberikan efek sedasi, amnesia, menghilangkan kecemasan.
Eva Susana Putri +2 more
doaj +1 more source
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]
, 2008 The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode +19 more
core +3 more sources
Midazolam for sedation before procedures in adults and children: a systematic review update
Systematic Reviews, 2021 Background Midazolam is used for sedation before diagnostic and therapeutic medical procedures by several routes including oral, intravenous, intranasal and intramuscular. This is an update of a Cochrane review published in 2016, which aimed to determine
Aaron Conway +3 more
doaj +1 more source
Vocal learning promotes patterned inhibitory connectivity. [PDF]
, 2017 Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear.
Brainard, Michael S +2 more
core +2 more sources
Journal of Pain and Symptom Management, 2002 Significant distress is experienced by patients, families, and caregivers when a symptom or disorder, such as an agitated delirium, becomes an intractable, or a catastrophic event, such as irreversible stridor. When palliative sedation is indicated for these patients, midazolam is usually the preferred drug.
Célia Roemer-Becuwe +2 more
openaire +2 more sources
Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]
, 2019 Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska +7 more
core +1 more source
The influence of DNA polymorphism of multidrug resistant 1 (MDR1) on the effect of midazolam pretreatment in children [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundPatients showed a different response following intravenous midazolam injection. Some children showed irritability or were not sedated by midazolam.
Hyo-Jin Byon +5 more
doaj +1 more source
A Case of Midazolam Anaphylaxis
Clinical Endoscopy, 2014 Midazolam is a type of anesthetic agent frequently used for conscious sedation during a variety of medical procedures. Anaphylactic reactions to midazolam are rarely reported. However, we observed a case of midazolam hypersensitivity in which emergency measures were required to ensure patient recovery after administration of midazolam as a sedative ...
Jae Gyu Shin +7 more
openaire +3 more sources
BMC Anesthesiology, 2022 Background The benzodiazepine midazolam is a γ-aminobutyric acid (GABA)-A receptor agonist frequently used for sedation or stress control in patients suffering from traumatic brain injury (TBI).
Anne Sebastiani +3 more
doaj +1 more source