Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review
International Journal of Pediatrics, 2014 Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd)
Gian Maria Pacifici
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High rates of midazolam injection among drug users in Bangkok, Thailand
Harm Reduction Journal, 2010 Background Reports from Thailand suggest that a growing number of people who inject drugs (IDU) are now injecting midazolam, a legal benzodiazepine with potent amnestic and ventilatory depressant effects.
Suwannawong Paisan +7 more
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Ain Shams Journal of Anesthesiology, 2022 Background Interaction with medical providers is a stressful experience for a child. The current study aimed to assess the efficacy and safety of intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation prior to ...
Noha A. Osama +3 more
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Comparison of nasal Midazolam with Ketamine versus nasal Midazolam as a premedication in children
Saudi Journal of Anaesthesia, 2014 Background: T his study was done to compare effects of intranasal midazolam and intranasal midazolam with ketamine for premedication of children aged 1-12 yrs undergoing intermediate and major surgeries.
Sonal S Khatavkar, Rochana G Bakhshi
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Paediatric anaesthesia, 2019 One of the most widely used options for minimal/moderate sedation in pediatric patients is oral midazolam, as it presents an alternative to less well‐accepted routes of administration (eg, intravenous or intranasal) of this well‐known efficacious and ...
M. Manso +3 more
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Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies [PDF]
, 2020 Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited
Huebinger, Ryan M. +7 more
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Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine [PDF]
, 2003 OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness. DESIGN: Pragmatic, randomised clinical trial. SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil. SUBJECTS:
Abreu, A.M. +13 more
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Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
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Anesthesiology, 2018 What We Already Know about This Topic Dexmedetomidine reduces cellular apoptosis, and it has been demonstrated previously that this antiapoptotic effect can not only increase cancer cell proliferation and migration but also reduce survival in ...
Chun-yan Wang +9 more
semanticscholar +1 more source
Intravenous conscious sedation in patients under 16 years of age. Fact or fiction? [PDF]
, 2003 Recently published guidelines on the use of conscious sedation in dentistry have published varying recommendations on the lower age limit for the use of intravenous conscious sedation.
J A Leitch +3 more
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