Results 41 to 50 of about 122,656 (259)

Understanding the mechanisms of floor plate specification in the vertebrate midbrain and its functions during development [PDF]

, 2009
textWe have previously shown that the arcuate organization of cell fates within the ventral midbrain critically depends upon the morphogen, Sonic Hedgehog (SHH), which is secreted from a signaling center located along the ventral midline, called the ...
Bayly, Roy Downer, 1981-
core  

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging

Frontiers in Genetics, 2020
Dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as Parkinson’s disease and schizophrenia. Genetic variation between individuals can affect the integrity and function of dopaminergic neurons but the DNA ...
Yujuan Gui, Mélanie H. Thomas, Pierre Garcia, Pierre Garcia, Pierre Garcia, Mona Karout, Rashi Halder, Alessandro Michelucci, Alessandro Michelucci, Heike Kollmus, Cuiqi Zhou, Shlomo Melmed, Klaus Schughart, Klaus Schughart, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Joseph H. Nadeau, Joseph H. Nadeau, Robert W. Williams, Thomas Sauter, Manuel Buttini, Lasse Sinkkonen   +25 more
doaj   +1 more source

Bilateral third and fourth cranial nerve palsy presenting secondary to central nervous system tuberculoma: A rare case report

Indian Journal of Ophthalmology. Case Reports, 2023
Central nervous system (CNS) tuberculoma can have variable presentations depending on the site and number of tuberculomas. We report a rare case of a 48-year-old male presenting with ptosis and binocular double vision.
Arumugam Balraj, Aditya Anand
doaj   +1 more source

The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]

, 2006
Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Heinze, HJ, Bunzeck, N, Bernstein, HG, Gundelfinger, ED, Tischmeyer, W, Lauer, CJ, Duzel, E, Schott, BH, Seidenbecher, CI, Fenker, DB   +9 more
core  

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Fourier and midbrain modulation filterbanks.

, 2023
Modulation decomposition filters are shown for (A) the midbrain filterbank and (C) the Fourier-based filterbank, with each transfer function contoured at the 3dB level (50% power).
Monty A. Escabí (5105276), Fengrong He (14615045), Ian H. Stevenson (7450628)   +2 more
core   +1 more source

XeraBorg: Neural Control of Tail‐Flick Escape for Backward Propulsion in Cyborg Crayfish

Advanced Robotics Research, EarlyView.
This work presents the first controlled tail‐flick propulsion method for the cyborg Cherax quadricarinatus. Comprehensive experiments establish a foundational framework for using the crayfish's natural escape mechanism as a locomotion strategy, expanding its potential as an underwater and amphibious mobile robot.
H. Nhan Le, Oscar J. Davis, Lachlan Fitzgerald, Robbie Wilson, Christofer Clemente, P. Ross McAree, T. Nho Do, T. Thang Vo‐Doan   +7 more
wiley   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Distinct cholinergic circuits underlie discrete effects of reward on attention

Frontiers in Molecular Neuroscience
Attention and reward are functions that are critical for the control of behavior, and massive multi-region neural systems have evolved to support the discrete computations associated with each.
Kelly Runyon, Tung Bui, Sarah Mazanek, Alec Hartle, Katie Marschalko, William Matthew Howe   +5 more
doaj   +1 more source