Results 21 to 30 of about 122,656 (259)

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development

Frontiers in Genetics, 2021
Sonic hedgehog (Shh) signaling regulates multiple morphogenetic processes during embryonic neurogenesis and craniofacial skeletal development. Gpr161 is a known negative regulator of Shh signaling. Nullizygous Gpr161 mice are embryonic lethal, presenting
Sung-Eun Kim, Karla Robles-Lopez, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell, Richard H. Finnell, Richard H. Finnell   +12 more
doaj   +1 more source

Contextual novelty changes reward representations in the striatum [PDF]

, 2010
Reward representation in ventral striatum is boosted by perceptual novelty, although the mechanism of this effect remains elusive. Animal studies indicate a functional loop (Lisman and Grace, 2005) that includes hippocampus, ventral striatum, and ...
Dolan, R J, Bunzeck, N, Stephan, K., Düzel, E, Dolan, R. ; https://orcid.org/, Düzel, E., Guitart-Masip, M. ; https://orcid.org/, Dolan, R. J., Guitart-Masip, M, Guitart-Masip, M., Stephan, K E, Bunzeck, N., Stephan, K. E.   +12 more
core   +1 more source

Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain

Frontiers in Molecular Neuroscience, 2018
Studies proposed a model for embryonic neurogenesis where the expression levels of the SOXB2 and SOXB1 factors regulate the differentiation status of the neural stem cells. However, the precise role of the SOXB2 genes remains controversial.
Neoklis Makrides, Elena Panayiotou, Pavlos Fanis, Christos Karaiskos, George Lapathitis, Stavros Malas   +5 more
doaj   +1 more source

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +1 more source

Morphometry MRI in the differential diagnosis of parkinsonian syndromes Morfometria por ressonância magnética no diagnóstico diferencial das síndromes parkinsonianas

Arquivos de Neuro-Psiquiatria, 2010
This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA).
Rômulo L Gama, Daniel F.G Távora, Rodrigo C Bomfim, Cruiff E Silva, Veralice M. de Bruin, Pedro F. de Bruin   +5 more
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A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

eLife, 2020
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS).
Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder   +14 more
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Exemplary midbrain raphe sonograms.

, 2022
Transcranial axial sonogram of the midbrain in (A) a healthy woman, (B) a woman with fibromyalgia syndrome, and (C) a woman with depression and physical pain. Midbrain raphe echogenicity (arrow) is markedly lower in B and C compared to A. The midbrain is
Dimitar Evdokimov (8292651), Stefan Unterecker (9135333), Nurcan Üçeyler (226246), Mira Schließer (14135072), Jakub Radziwon (14135075), Betty Feulner (14135078), Uwe Walter (5769878), Florian Rimmele (11181128)   +7 more
core   +1 more source

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Stem Cell Reports, 2017
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD).
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel   +11 more
doaj   +1 more source

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Stem Cell Reports, 2017
Research on human brain development and neurological diseases is limited by the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Here, we describe a robust human brain organoid system that is highly
Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn   +13 more
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Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons

Frontiers in Cellular Neuroscience, 2021
Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. They contribute to synaptic transmission, neuronal differentiation and neurodegeneration.
Andreas Neuhof, Andreas Neuhof, Yuemin Tian, Anna Reska, Björn H. Falkenburger, Stefan Gründer   +5 more
doaj   +1 more source