Results 21 to 30 of about 98,891 (266)

Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain

Frontiers in Molecular Neuroscience, 2018
Studies proposed a model for embryonic neurogenesis where the expression levels of the SOXB2 and SOXB1 factors regulate the differentiation status of the neural stem cells. However, the precise role of the SOXB2 genes remains controversial.
Neoklis Makrides, Elena Panayiotou, Pavlos Fanis, Christos Karaiskos, George Lapathitis, Stavros Malas   +5 more
doaj   +1 more source

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +1 more source

Morphometry MRI in the differential diagnosis of parkinsonian syndromes Morfometria por ressonância magnética no diagnóstico diferencial das síndromes parkinsonianas

Arquivos de Neuro-Psiquiatria, 2010
This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA).
Rômulo L Gama, Daniel F.G Távora, Rodrigo C Bomfim, Cruiff E Silva, Veralice M. de Bruin, Pedro F. de Bruin   +5 more
doaj   +1 more source

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

eLife, 2020
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS).
Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder   +14 more
doaj   +1 more source

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Stem Cell Reports, 2017
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD).
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel   +11 more
doaj   +1 more source

Midbrain vasculitic aneurysms [PDF]

Neurology, 2004
This 16-year-old girl had a muscle biopsy demonstrating vasculitis seven years ago when she presented with weakness and Raynaud’s phenomenon (figure, B). Aside from occasional unexplained abdominal pain and chronic anemia, she had been well until one year ago, …
Hyung-Min, Kwon, Jae-Kyu, Roh, Gregory Youngnam, Chang   +2 more
openaire   +2 more sources

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Stem Cell Reports, 2017
Research on human brain development and neurological diseases is limited by the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Here, we describe a robust human brain organoid system that is highly
Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn   +13 more
doaj   +1 more source

Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons

Frontiers in Cellular Neuroscience, 2021
Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. They contribute to synaptic transmission, neuronal differentiation and neurodegeneration.
Andreas Neuhof, Andreas Neuhof, Yuemin Tian, Anna Reska, Björn H. Falkenburger, Stefan Gründer   +5 more
doaj   +1 more source

Hematoma tegmento-mesencefálico espontâneo: aspectos neurocomportamentais do terço rostral do tronco encefálico humano Spontaneous tegmento-mesencephalic hematoma: neurobehavioral insights concerning the rostral human brainstem

Arquivos de Neuro-Psiquiatria, 1995
O tegmento do mesencéfalo é área complexa, dada a quantidade de fibras que o atravessam, provenientes de circuitos locais, de sistemas ativadores ascendentes e de feixes descendentes dos hemisférios cerebrais.
Ricardo de Oliveira-Souza, Márcio Luciano de Souza Bezerra, Wagner Martignoni de Figueiredo, Pedro Ângelo Andreiuolo   +3 more
doaj   +1 more source

Altered brain connectivity in Long Covid during cognitive exertion: a pilot study

Frontiers in Neuroscience, 2023
IntroductionDebilitating Long-Covid symptoms occur frequently after SARS-COVID-19 infection.MethodsFunctional MRI was acquired in 10 Long Covid (LCov) and 13 healthy controls (HC) with a 7 Tesla scanner during a cognitive (Stroop color-word) task.
Leighton Barnden, Kiran Thapaliya, Kiran Thapaliya, Natalie Eaton-Fitch, Markus Barth, Markus Barth, Sonya Marshall-Gradisnik   +6 more
doaj   +1 more source