Results 51 to 60 of about 122,656 (259)

Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output

eLife, 2019
Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear ...
Kristina M Wright, Michael A McDannald
doaj   +1 more source

Brainstem Organoids From Human Pluripotent Stem Cells

Frontiers in Neuroscience, 2020
The brainstem is a posterior region of the brain, composed of three parts, midbrain, pons, and medulla oblongata. It is critical in controlling heartbeat, blood pressure, and respiration, all of which are life-sustaining functions, and therefore, damages
Nobuyuki Eura, Takeshi K. Matsui, Takeshi K. Matsui, Joachim Luginbühl, Masaya Matsubayashi, Hitoki Nanaura, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng, Tsukasa Kouno, Yan Jun Lan, Pornparn Kongpracha, Pattama Wiriyasermkul, Yoshihiko M. Sakaguchi, Riko Nagata, Tomoya Komeda, Naritaka Morikawa, Fumika Kitayoshi, Miyong Jong, Shinko Kobashigawa, Mari Nakanishi, Masatoshi Hasegawa, Yasuhiko Saito, Takashi Shiromizu, Yuhei Nishimura, Takahiko Kasai, Maiko Takeda, Hiroshi Kobayashi, Yusuke Inagaki, Yasuhito Tanaka, Manabu Makinodan, Toshifumi Kishimoto, Hiroki Kuniyasu, Shushi Nagamori, Alysson R. Muotri, Alysson R. Muotri, Jay W. Shin, Kazuma Sugie, Eiichiro Mori   +41 more
doaj   +1 more source

Biophysical study of neuronal networks in midbrain organoids derived from Parkinson's disease patients

, 2022
reservedIn vitro approaches to model human brain development and disease are an intense area of research. In the context of Parkinson's disease (PD), human midbrain organoids (hMOs) are significatively relevant, as they generate dopaminergic neurons ...
MARINO, SARALEA
core  

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1

Frontiers in Neuroanatomy, 2015
The red nucleus is a neuronal population that plays an important role in forelimb motor control and locomotion. Histologically it is subdivided into two subpopulations, the parvocellular red nucleus located in the diencephalon and the magnocellular red ...
Jesus E. eMartinez-Lopez, Juan A. eMoreno-Bravo, M. Pilar eMadrigal, Salvador eMartinez, Salvador eMartinez, Eduardo ePuelles   +5 more
doaj   +1 more source

Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation

Stem Cell Reports, 2023
Summary: Stem cell technologies provide new opportunities for modeling cells in health and disease and for regenerative medicine. In both cases, developmental knowledge and defining the molecular properties and quality of the cell types is essential.
Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilía Sif Ásgrímsdóttir, Kasra Nikouei, Wojciech Paslawski, Sabine Gnodde, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arenas   +13 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

THE EFFECT OF SINGLE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL ON THE CONTENT OF NEUROACTIVE AMINO ACIDS IN THE BRAIN OF RATS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present.
Velichko I. M., Lelevich S. V., Lelevich V. V.   +2 more
doaj   +1 more source

Unique case of midbrain tuberculoma presenting as isolated inferior rectus palsy with nystagmus

Indian Journal of Ophthalmology, 2018
Isolated brain stem tuberculoma constitutes about 5% of all intracranial tuberculomas. A case of isolated inferior rectus palsy with downbeat nystagmus due to presumed midbrain tuberculoma in an immunocompetent patient is described here.
Akkayasamy Kowsalya, Umang Gajarlewar, Namrata G Adulkar, S Mahesh Kumar   +3 more
doaj   +1 more source