Results 61 to 70 of about 122,656 (259)
Neuromorphic Devices and Computing for Sensing, Memory, and Control
Advanced Science, EarlyView.This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu +2 more
wiley +1 more source
eLife, 2019 The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear output ...
Kristina M Wright +3 more
doaj +1 more source
Midbrain injury in patients with subarachnoid hemorrhage: a diffusion tensor imaging study
Scientific Reports, 2022 We investigated the characteristics of midbrain injuries in patients with spontaneous subarachnoid hemorrhage (SAH) by using diffusion tensor imaging (DTI).
Sung Ho Jang, Young Hyeon Kwon
doaj +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Frontiers in Psychology, 2020 Successful learning requires the control of attention to monitor performance and compare actual versus expected outcomes. Neural activity in the ventral tegmental area (VTA) has been linked to attention control in animals.
Ping C. Mamiya +3 more
doaj +1 more source
, 2015 In this chapter, the midbrain is discussed and its individual components. The midbrain is comprised of the cerebral peduncles, tectum and the ventral portion.
Paul Rea, Rea, Paul M.
core +1 more source
Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression [PDF]
, 2013 During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this signaling mechanism is important for developing therapies for neurodegenerative illnesses.
core +1 more source
Advanced Science, EarlyView.This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu +23 more
wiley +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
Modeling Parkinson's disease using human midbrain organoids
, 2019 With increasing prevalence, neurodegenerative disorders present a major challenge for medical research and public health. Despite years of investigation, significant knowledge gaps exist, which impede the development of disease-modifying therapies ...
MONZEL, Anna Sophia
core +1 more source