Single‐Cell RNA‐seq Reveals Deubiquitination Genes as Prognostic Markers in Hepatocellular Carcinoma
International Journal of Genomics, Volume 2026, Issue 1, 2026.Background Hepatocellular carcinoma (HCC) carries a dismal prognosis, yet the contribution of deubiquitination—an essential posttranslational regulator—to its progression remains poorly defined. Methods Single‐cell RNA‐seq profiles of 13 treatment‐naïve HCC tumors were integrated with 374 TCGA and 243 ICGC bulk RNA‐seq cohorts.
Xuening Lv +5 more
wiley +1 more source
Systemic inflammation, nutritional status and survival in patients with cancer [PDF]
, 2009 Systemic inflammation, nutritional status and survival in patients with ...
Al Murri +33 more
core +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng +14 more
wiley +1 more source
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter +6 more
core
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers [PDF]
, 2013 Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor
Brown, G. +14 more
core +3 more sources
Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases [PDF]
British Journal of Pharmacology, 2014 Midkine (MK) is a pleiotropic growth factor prominently expressed during embryogenesis but down‐regulated to neglible levels in healthy adults. Many published studies have demonstrated striking MK overexpression compared with healthy controls in various pathologies, including ischaemia, inflammation, autoimmunity and, most notably, in many cancers.
openaire +2 more sources
Host chemokine signature as a biomarker for the detection of pre-cancerous cervical lesions [PDF]
, 2018 Background The ability to distinguish which hrHPV infections predispose to significant disease is ever more pressing as a result of the increasing move to hrHPV testing for primary cervical screening.
Bhatia, Ramya +11 more
core +2 more sources
Leukocyte Receptor Tyrosine Kinase interacts with secreted midkine to promote survival of migrating neural crest cells [PDF]
, 2018 Neural crest cells migrate long distances throughout the embryo and rely on extracellular signals that attract, repel and/or stimulate survival to ensure proper contribution to target derivatives.
Bronner, Marianne E. +1 more
core +1 more source
Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome [PDF]
, 2016 © 2016 John Wiley & Sons Ltd Context: Animal studies suggest that cannabinoid receptor-1 (CB-1) blockade reduces inflammation and neovascularization by decreasing vascular endothelial growth factor (VEGF) levels associated with a reduction in ...
Atkin, Stephen L. +4 more
core +1 more source