Results 101 to 110 of about 6,907 (199)
Characterising the Periodontal Granulation Tissue Using scRNAseq
Journal of Clinical Periodontology, Volume 53, Issue 2, Page 308-320, February 2026.ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu +7 more
wiley +1 more source
eLife, 2020 Formation of a specialized wound epidermis is required to initiate salamander limb regeneration. Yet little is known about the roles of the early wound epidermis during the initiation of regeneration and the mechanisms governing its development into the ...
Stephanie L Tsai +2 more
doaj +1 more source
Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]
, 2017 Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G +2 more
core +3 more sources
The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Leukocyte Receptor Tyrosine Kinase interacts with secreted midkine to promote survival of migrating neural crest cells [PDF]
, 2018 Neural crest cells migrate long distances throughout the embryo and rely on extracellular signals that attract, repel and/or stimulate survival to ensure proper contribution to target derivatives.
Bronner, Marianne E. +1 more
core +1 more source
Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases [PDF]
British Journal of Pharmacology, 2014 Midkine (MK) is a pleiotropic growth factor prominently expressed during embryogenesis but down‐regulated to neglible levels in healthy adults. Many published studies have demonstrated striking MK overexpression compared with healthy controls in various pathologies, including ischaemia, inflammation, autoimmunity and, most notably, in many cancers.
openaire +2 more sources
NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins [PDF]
, 2011 Background: Nucleolar localization sequences (NoLSs) are short targeting sequences responsible for the localization of proteins to the nucleolus. Given the large number of proteins experimentally detected in the nucleolus and the central role of this ...
Michelle S Scott +2 more
core +1 more source
Oocytes recovered from cows treated with retinol become unviable as blastocysts produced in vitro [PDF]
, 2011 Retinoids have been shown to enhance developmental competence of the oocyte in cattle, sheep and pigs. In this study we investigated whether exogenous retinol stimulates the bovine oocyte during its intrafollicular growth and the time limits of exposure ...
Alonso, Cristina +10 more
core
Targets for cancer therapy in childhood sarcomas [PDF]
, 2010 Development of chemotherapeutic treatment modalities resulted in a dramatic increase in the survival of children with many types of cancer. Still, in case of some pediatric cancer entities including rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma ...
Amstutz +195 more
core +1 more source