Results 111 to 120 of about 6,987 (195)

Frontiers in Pigment Cell and Melanoma Research

, 2018
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca, Bosenberg, Marcus W., Box, Neil F., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Filipp, Fabian V., Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Poole, Caroline Le, Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S.   +26 more
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Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Ovariectomy Alters Gene Expression of the Hippocampal Formation in Middle-Aged Rats [PDF]

, 2016
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During 29 menopause, this complex signaling declines, leading to impaired learning and memory.
Hrabovszky, Erik, Kalló, Imre, Liposits, Zsolt, Solymosi, Norbert, Sárvári, Miklós   +4 more
core   +1 more source

Pregnancies and improved early embryonic development with bovine oocytes matured in vitro with 9-cis-retinoic acid [PDF]

, 2010
Retinoids have an important role in cell growth, morphogenesis and differentiation. In the present study the developmental potential of bovine oocytes was examined after in vitro maturation in the presence of 9-cis-retinoic acid, a vitamin A metabolite ...
Duque, Paloma, Díez, Carmen, Facal, Nieves, Gómez, Enrique, Hidalgo, C.O. (Carlos)   +4 more
core  

Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]

, 2017
Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G, Haderk, Franziska, Wu, Wei   +2 more
core   +3 more sources

Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC), one of the leading causes of cancer deaths in the world, is offering a challenge to human beings, with the current modes of treatment being a palliative approach.
Chauhan, Ranjit
core   +1 more source

Enhancement of developmental capacity of meiotically inhibited bovine oocytes by retinoic acid [PDF]

, 2012
BACKGROUND: Although high vitamin A may be teratogenic to the embryo, retinol has been shown to support oocyte developmental potential in vivo. Similarly, addition of retinol metabolite 9-cis-retinoic acid to in-vitro cultured oocytes could promote ...
Carneiro, G., Duque, Paloma, Díez, C., Facal, Nieves, Gómez, E., Hidalgo, C.O. (Carlos), Lorenzo, P.L. (Pedro), Royo, L.J. (Luis)   +7 more
core  

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development

Frontiers in Pharmacology, 2019
Inflammation is a common factor of pathologies such as obesity, type 2 diabetes or neurodegenerative diseases. Chronic inflammation is considered part of the pathogenic mechanisms of different disorders associated with aging.
Gonzalo Herradon, M. Pilar Ramos-Alvarez, Esther Gramage   +2 more
doaj   +1 more source

Heparin-binding growth-associated molecule (HB-GAM) in activity-dependent neuronal plasticity in hippocampus [PDF]

, 2005
Cell adhesion and extracellular matrix (ECM) molecules play a significant role in neuronal plasticity both during development and in the adult. Plastic changes in which ECM components are implicated may underlie important nervous system functions, such ...
Pavlov, Ivan
core   +1 more source

Serum Midkine as a Potential Biomarker Associated with Disease Severity and Remodeling-Related Mediators in Children with Asthma

Journal of Asthma and Allergy
Yongtian Xu,* Lixia Zhao,* Yingying Mi, Yi Ge, Yanfang Guo Department of Pediatrics, Shanghai University of Medicine and Health Science Affiliated Gongli Hospital, Shanghai, People’s Republic of China*These authors contributed ...
Xu Y, Zhao L, Mi Y, Ge Y, Guo Y
doaj