Results 71 to 80 of about 624 (180)

Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction

The inhibition of gamma-butyrobetaine (GBB) hydroxylase, a key enzyme in the biosynthesis of carnitine, contributes to lay ground for the cardioprotective mechanism of action of mildronate.
Pugovičs, Osvalds, Loča, Dagnija, Kalviņš, Ivars, Vilskersts, Reinis, Liepiņš, Edgars, Kirjanova, Olga, Dambrova, Maija   +6 more
core  

Neurothropic effects of mildronate, an inhibitor of L-carnitine biosynthesis, in experimental models

, 2014
Promocijas darba mērķis bija noskaidrot mildronāta terapijas neirotropos efektus un izpētīt šo efektu regulācijas molekulāros mehānismus saistībā ar Lkarnitīnu.
Švalbe, Baiba, Baiba Švalbe
core  

Unlocking the Potential of Meldonium: From Performance Enhancement to Therapeutic Insights

Psychoactives
Meldonium, a promising pharmacological agent initially developed for cardiovascular indications, has sparked considerable interest in recent years due to its potential performance-enhancing effects.
Val Bellman
doaj   +1 more source

MAIN THERAPEUTIC PRINCIPLES IN PREMENOPAUSAL WOMEN

Российский кардиологический журнал, 2011
The review outlines the main mechanisms of protective estrogen effects on cardiovascular system and the role of estrogen deficiency in cardiovascular disease (CVD) development. The position of the International Menopause Society (2009) on CVD in women is
S. N. Tolstov, I. A. Salov, V. B. Mychka, M. Yu. Kirillova, N. A. Voychenko, I. V. Kuznetsova   +5 more
doaj  

Solid herbal extract of Primula veris L. improves morphofunctional condition of rats' myocardium in chronic alcohol intoxication. [PDF]

J Tradit Complement Med, 2023
Prokofiev II, Kustova MV, Nesterova AA, Perfilova VN, Khusainova GH, Borodkina LE, Tivon YV, Tyurenkov IN, Kataev VA, Latypova GM.   +9 more
europepmc   +1 more source

EFFECTS OF MILDRONATE, AS A PART OF COMBINED HEART FAILURE THERAPY, ON CARBOHYDRATE AND LIPID METABOLISM AND OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Российский кардиологический журнал, 2010
In total, 100 patients aged 45-70 years, with Functional Class (FC) II-III chronic heart failure (CHF) and compensated or sub-compensated Type 2 diabetes mellitus (DM-2) were examined.
M. E. Statsenko, S. V. Turkina, S. V. Belenkova, L. V. Poletaeva, G. P. Dudchenko   +4 more
doaj  

Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy

Российский кардиологический журнал, 2005
Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a ...
I. G. Gordeev, E. E. Ilina, V. A. Lusov, N. A. Volov, E. A. Bekchiu, A. Yu. Lebedeva   +5 more
doaj  

CLINICAL EFFECTIVENESS AND ANTIOXIDANT ACTIVITY OF MILDRONATE IN ISCHEMIC STROKE

Российский кардиологический журнал, 2009
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M. Yu. Maksimova, B. A. Kistenev, M. A. Domashenko, T. N. Fedorova, T. N. Sharypova   +4 more
openaire   +1 more source

[Biochemical mechanisms of mildronate action during ischemic stress].

Likars'ka sprava, 2004
The authors in the article described biochemical mechanisms of Mildronat. The main mechanism of Mildronat activity is based on decreasing carnitine level in the organism, which leads to hampering oxidation of fatty acids. Mildronat is believed keeps on training myocardium pharmacologically even without physical activity by adapting cells to decreasing ...
M, Dambrova, D, Daĭia, E, Liepin'sh, O, Kir'ianova, I, Kalvin'sh   +4 more
openaire   +1 more source

Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish. [PDF]

J Biol Chem, 2023
Zhou WH, Luo Y, Li RX, Degrace P, Jourdan T, Qiao F, Chen LQ, Zhang ML, Du ZY.   +8 more
europepmc   +1 more source