Results 61 to 70 of about 1,043,065 (315)

Milk, coronary heart disease and mortality [PDF]

open access: yes, 2001
<b>STUDY OBJECTIVE</b> To study the association between reported milk consumption and cardiovascular and all cause mortality. <b>DESIGN</b> A prospective study of 5765 men aged 35-64 at the time of examination.
Davey Smith, G., Hart, C.L., Ness, A.
core   +1 more source

Exploration of non-coding RNAs related to intramuscular fat deposition in Xinjiang Brown cattle and Angus × Wagyu cattle

open access: yesBMC Genomics
Non-coding RNAs (ncRNAs) serve as crucial regulatory elements in the process of adipogenesis in animals; however, the specific roles and interrelationships of ncRNAs in bovine fat deposition remain poorly understood.
Yuxin Zhou   +9 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The capacity to expand milk production in Ireland following the removal of milk quotas [PDF]

open access: yes, 2012
peer-reviewedGiven the imminent removal of milk quota in 2015, EU dairy farmers will be able to expand production without purchasing milk quota rights for the first time in 30 years.
Lapple, Doris, Hennessy, Thia
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Ion speciation in milk-like systems [PDF]

open access: yes, 2010
The research described in this thesis is about ion behaviour in milk systems as a function of changing conditions (pH, ionic strength, addition of electrolytes and non-electrolytes).
Gao, R.
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A survey on composition and microbiota of fresh and fermented yak milk at different Tibetan altitudes [PDF]

open access: yes, 2009
Yak milk is a type of milk that people are less familiar with due to its remote geographical location, the particular geographical environment and climatic conditions in Tibet, which may have significant effects on composition, microbiota and ...
Li Yu   +17 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

IMPACT OF MILK COOPERATIVES ON MARKETED SURPLUS OF MILK [PDF]

open access: yes
The study conducted during 1994-95 in Jalgaon and Kolhapur districts of Maharashtra showed two differing scenarios insofar as the impact of milk cooperatives on production and marketed surplus is concerned.
Shah, Deepak
core   +1 more source

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