Results 41 to 50 of about 1,210,676 (315)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Mandatarios al banquillo: los legados de la jurisprudencia de los tribunales AD HOC y desafíos actuales para la corte penal internacional en el juzgamiento de los jefes de estado en funciones

Thēmis, 2013
En el presente artículo, la autora analiza el fenómeno político e internacional contemporáneo que ha empezado a darse de forma acelerada desde el final de Guerra Fría y con el reciente proceso denominado “la Primavera Árabe”: Los juicios realizados ...
Michelle Reyes Milk
doaj  

Effect of Holder pasteurization on nutrient and immune component retention in human milk: a comparison between water and dry pasteurizers

International Breastfeeding Journal
Background Holder pasteurization (HoP; 62.5 °C, 30 min) is the method used most frequently in human milk banks to reduce the risk of infection transmission through donor human milk (DHM), but it has the disadvantage of potentially affecting the contents ...
Miori Tanaka, Midori Date, Kasumi Takayama, Nagisa Matsuura, Katsumi Mizuno   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Virucidal Influence of Ionic Liquids on Phages P100 and MS2

Frontiers in Microbiology, 2017
An increasing number of publications describe the potential of ionic liquids (ILs) as novel antimicrobials, antibacterial coatings and even as active pharmaceutical ingredients. Nevertheless, a major research area, notably their impact on viruses, has so
Susanne Fister, Patrick Mester, Julia Sommer, Anna K. Witte, Roland Kalb, Martin Wagner, Peter Rossmanith, Peter Rossmanith   +7 more
doaj   +1 more source

Ion speciation in milk-like systems [PDF]

, 2010
The research described in this thesis is about ion behaviour in milk systems as a function of changing conditions (pH, ionic strength, addition of electrolytes and non-electrolytes).
Gao, R.
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

New latex agglutination assay for the determination of lactoferrin in human milk

International Breastfeeding Journal
Background Lactoferrin (LF) in human milk has various biological properties and contributes to the prevention of preterm birth complications. Enzyme-linked immunosorbent assay (ELISA) is one of the most commonly used methods to measure LF in human milk ...
Miori Tanaka, Midori Date, Katsumi Mizuno   +2 more
doaj   +1 more source

Valorisation of Whey and Buttermilk for Production of Functional Beverages – An Overview of Current Possibilities

Food Technology and Biotechnology, 2019
Whey and buttermilk are the main by-products of the dairy industry, both having excellent nutritional properties. Buttermilk contains a unique component, the milk fat globule membrane (MFGM). MFGM contains bioactive compounds with positive health effects
Irena Barukčić, Katarina Lisak Jakopović, Rajka Božanić   +2 more
doaj   +1 more source

MC4R gene polymorphism and its association with meat traits of Karachai sheep grown in Russian Federation

Journal of Applied Animal Research, 2021
This paper presents the results on the study of melanocortin-4 receptor (MC4R) gene polymorphisms in sheep of the Karachai breed. AA, AG, and GG genotypes were determined to have allele frequencies of 47%, 37%, and 16%, respectively, indicating that ...
Ivan Fiodorovich Gorlov, Nadezhda Vasilievna Shirokova, Elena Yurievna Anisimova, Marina Ivanovna Slozhenkina, Yuriy Anatolievich Kolosov, Arkadiy Kanurovich Natyrov, Anatoliy Yurievich Kolosov, Natalia Ivanovna Mosolova, Maria Anatolievna Kolosova, Timur Tazretovich Tarchokov, Aleksandr Anatolievich Mosolov, Daria Aleksandrovna Mosolova, Ekaterina Vladimirovna Karpenko   +12 more
doaj   +1 more source