Results 31 to 40 of about 1,210,676 (315)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Derecho PUCP, 2014 El presente artículo analiza la situación actual en Siria a la luz del derecho penal internacional y el derecho internacional humanitario. El artículo se enfoca, principalmente, en los desarrollos que tuvieron lugar a partir de mediados de 2013 hasta ...
Michelle Reyes Milk
doaj
A Fast and Easy ATP-Based Approach Enables MIC Testing for Non-resuscitating VBNC Pathogens
Frontiers in Microbiology, 2019 Many bacteria enter the viable but non-culturable (VBNC) state to maximize resources and increase their tolerance to harmful conditions to cope with environmental stress, which has been described for a plethora of important human and foodborne pathogens.
Christian Robben +7 more
doaj +1 more source
Frontiers in Nutrition, 2023 The importance of food components to potential benefits and risks to human health is gradually being consumer awareness. Milk is an important part of the lipid content of the human diet, and there are few detailed reports on the fatty acid (FA) profiles ...
Meiqing Chen +14 more
doaj +1 more source
Studies in the Maternal, 2018 Milk, myth and breastfeeding.
Jackson, Melanie, Esther, Leslie
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Frontiers in Microbiology, 2018 The eradication of Listeria monocytogenes from food chains is still a great challenge for the food industry and control authorities since some clonal complexes (CCs) are either better adapted to food processing environments (FPEs) or are globally ...
Meryem Muhterem-Uyar +7 more
doaj +1 more source
Analysis of the efficiency of production of whole-muscle turkey products with vegetable sprinkles
Теория и практика переработки мяса, 2022 Human health is largely determined by the nature, level and structure of nutrition. A promising direction in the development of new food products is the expansion of the base of used ingredients used to partially replace meat raw materials with vegetable
I. E. Gorlov +5 more
doaj +1 more source