Results 71 to 80 of about 2,300,834 (356)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Infusion pasteurization of skim milk: Effects of different time-temperature combinations [PDF]

open access: yes, 2007
Infusion pasteurization technology was used in different time-temperature combinations for heat treatment of skim milk and compared to untreated skim milk and a standard pasteurization treatment.
Hammershøj, M.   +2 more
core  

Differential leukocyte count method for bovine low somatic cell count milk [PDF]

open access: yes, 2003
Whereas many differential leukocyte count methods for high somatic cell count (SCC) milk from mastitic cows are available, only a few have been developed for low SCC milk.
Burvenich, Christian   +4 more
core   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Development of an efficient milk production profile of the Irish dairy Industry [PDF]

open access: yes, 2008
End of project reportFluctuation around milk price will be the biggest factor that the dairy industry will experience over the next number of years. This fluctuation is being driven by fluctuation on the world dairy markets.
Dillon, Pat   +2 more
core  

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

HUBUNGAN ANTARA PERSEPSI TENTANG SUSU FORMULA DENGAN INTENSI MEMBELI [PDF]

open access: yes, 2009
For a few Indonesia society moment have been re-caused an uproar regarding the problem of health world with invention of bacterium of Enterobacter Sakazakii ( E.
PROVITASARI, AGUSTINA
core  

Volatile organic compounds and consumer preference for meat from suckling goat kids raised with natural or replacers milk [PDF]

open access: yes, 2019
Most of European Union goats are slaughtered with carcase weights between 5 kg and 11 kg. Some farmers rear kids with milk replacers to produce cheese with the dams’ milk.
Alcalde Aldea, María Jesús   +6 more
core   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells

open access: yesMicroorganisms, 2020
Gut microbiota-derived tryptophan metabolites such as indole derivatives are an integral part of host metabolome that could mediate gut−brain communication and contribute to host homeostasis.
Chyn Boon Wong   +3 more
doaj   +1 more source

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