Results 51 to 60 of about 26,469 (297)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Impact of applying hygienic practices at farm on bacteriological quality of raw milk [PDF]

Veterinary World, 2014
Aim: The present study was carried out to explore the potential source of contamination and the efficacy of different washing practices towards quality milk production. Materials and Methods: Probable sources of contamination viz.
N. Pandey, A. Kumari, A. K. Varma, S. Sahu , M. A. Akbar   +4 more
doaj   +1 more source

Effects of pulsation type (alternate and simultaneous) on mechanical milking of dairy goats (I) : A study in Alpine goats varying the system vacuum level

, 2016
The aim of this study was to assess the effect of alternate and simultaneous pulsation on milking performance (milk yield, machine stripping milk, milking duration, and average milk flow rate) of Alpine goats milked at two different system vacuum levels (
J. Bueso Ródenas, J. R. Díaz, F.M. Tangorra, GUIDOBONO CAVALCHINI, ANTONIOTTO, G. Romero   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Staphylococcus aureus of raw cow's milk

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2021
The presence of Staphylococcus aureus in raw milk is considered a direct danger to consumers. Almost all types of dairy products normalize the amount of Staphylococcus aureus in 1 g (cm3) of product, due to their ability to produce thermostable ...
M. D. Kukhtyn, Y. V. Horiuk, V. Z. Salata, V. T. Klymyk, N. M. Vorozhbit, T. M. Rushchinskaya   +5 more
doaj   +1 more source

Bias and accuracy of single milking testing schemes to estimate daily and lactation milk yield

, 1995
This study evaluated the adequacy of an alternate a.m.-p.m. testing scheme for milk yield in comparison with the official test method based on weighing two milkings within 24 h.
MANTOVANI, ROBERTO, CONTIERO, BARBARA, CASSANDRO, MARTINO, JANSEN GB, GALLO, LUIGI, CARNIER, PAOLO, BITTANTE, GIOVANNI   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Managmental Studies of Different Liquid Feeding Regimes for Nili-Ravi Buffalo Calves [PDF]

The Iranian Journal of Veterinary Science and Technology
A liquid feeding trial was carried out at the Dairy Animals Training and Research Centre, UVAS Ravi Campus, Pattoki, to explore effective methods for rearing Nili-Ravi buffalo calves using alternative feeding sources.
Ray Quddus, Asfand Khan, Muhammad Muneeb
doaj   +1 more source

Effect of 2-hydroxy-4-(methylthio)butanoate (HMTBa) on milk fat, rumen environment and biohydrogenation, and rumen protozoa in lactating cows fed diets with increased risk for milk fat depression

Journal of Dairy Science, 2022
: Biohydrogenation-induced milk fat depression (MFD) is a reduction in milk fat synthesis caused by bioactive fatty acids (FA) produced during altered ruminal microbial metabolism of unsaturated FA. The methionine analog 2-hydroxy-4-(methylthio)butanoate
M. Baldin, D. Garcia, G.I. Zanton, F. Hao, A.D. Patterson, K.J. Harvatine   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source