Results 61 to 70 of about 191,887 (294)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Spartan Daily, May 2, 2018 [PDF]

, 2018
Volume 150, Issue 39https://scholarworks.sjsu.edu/spartan_daily_2018/1038/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Determination of Volatile Compounds in Nut-Based Milk Alternative Beverages by HS-SPME Prior to GC-MS Analysis

Molecules, 2019
A reliable Headspace-Solid Phase Microextraction (HS-SPME) method was developed for the determination of polar volatile components of commercial nut-based milk alternative drinks prior to Gas Chromatography−Mass Spectrometry (GC-MS) analysis. Under
Natalia Manousi, George A. Zachariadis
doaj   +1 more source

The 'fat tax': economic incentives to reduce obesity [PDF]

, 2004
This Briefing Note looks at the potential for the introduction of a "fat tax" into the UK in an effort to reduce the growing prevalence of obesity in Britain. There are different forms such a tax could take.
Leicester, A., Windmeijer, F.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Geographic Differences in the Relative Price of Healthy Foods [PDF]

Although healthy foods can be affordable, if less healthy foods are cheaper, individuals may have an economic incentive to consume a less healthful diet.
Leibtag, Ephraim S., Penberthy, Corttney, Todd, Jessica E.   +2 more
core   +1 more source

Alternative agricultural policy scenarios, sector modelling and indicators - A sustainability assessment [PDF]

, 2004
In this article, we assess ecological, economic and social sustainability impacts of four alternative agricultural policy scenarios relevant to the European perspective.
Aakkula, Jyrki, Lehtonen, Heikki, Rikkonen, Pasi   +2 more
core  

Mathematical modelling in animal nutrition: a centenary review [PDF]

, 2008
A centenary review presents an opportunity to ponder over the processes of concept development and give thought to future directions. The current review aims to ascertain the ontogeny of current concepts, underline the connection between ideas and people
A. DUMAS, Armsby, Atwater, Baldwin, Baldwin, Beever, Bergman, Black, Black, Blaxter, Blaxter, Blaxter, Brody, Brody, Bureau, Curnow, Davidson, de Lange, Dent, Dijkstra, Ewing, Feller, Forbes, Forbes, Garfinkel, Garrett, Gayon, Headley, Henneberg, Hill, Hubbell, Hungate, J. DIJKSTRA, J. FRANCE, Johnson, Jull, Kellner, Kellner, Kevles, Kleiber, Kleiber, Koehler, Kriss, Kronfeld, Kyriazakis, Lehmann, Lerner, Lotka, Maynard, Maynard, McCollum, McCollum, Mercer, Michaelis, Mignon-Grasteau, Mitchell, Mitchell, Mitchell, Mitscherlich-Königsberg, Monod, Morris, Moulton, Murray, Nelson, Osborne, Osborne, Oslage, Pearl, Pirt, Porter, Ragsdale, Ratkowski, Ratkowski, Rice, Riley, Ritzman, Robertson, Robertson, Rubner, Schiemann, Schinckel, Schneider, Seber, Steele, Thaer, Thomas, Thorbek, Thornley, Tyler, Vande Wiele, Verhulst, Waters, Wenk, Weymouth, Wolff, Wolff   +95 more
core   +2 more sources