Results 71 to 80 of about 4,302,822 (311)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Effects of BLG polymorphism and dietary supplementation with carob pulp on ewe milk traits and fatty acid composition

open access: yesItalian Journal of Animal Science, 2023
The current study examined the effect on milk traits and composition of the replacement of barley grain with carob pulp as a supplement for grazing ewes with different genotypes at the β-lactoglobulin (BLG) locus.
Serena Tumino   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Variation in the Composition of Human Milk [PDF]

open access: yesThe Boston Medical and Surgical Journal, 1903
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Sharples, Philip P., Darling, Eugene A.
openaire   +1 more source

Human milk: composition and health benefits.

open access: yesLa Pediatria Medica e Chirurgica, 2017
Breastfeeding is widely acknowledged as the normal and unequalled method for feeding infants due to its associated health benefits, both for the infant and the mother.
F. Mosca, M. Giannì
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Effect of supplementary glycerin on milk composition and heat stability in dairy goats [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2017
Objective This experiment was studied the effects of various levels of crude glycerin (CG) in dairy goat diet on daily intake, milk yield, milk composition, some physical properties and some quality changes of goat milk after sterilization.
Deela Thoh   +2 more
doaj   +1 more source

Correlation between human milk composition and maternal nutritional status

open access: yesRoczniki Panstwowego Zakladu Higieny, 2018
Background Human milk is the optimal nutrition for newborns and infants during the first period of their life – from birth to 6-th month. It contains a uniquely quantitative and qualitative balanced nutrients profile.
A. Bzikowska   +3 more
semanticscholar   +1 more source

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