Results 121 to 130 of about 179,821 (344)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Milk Consumption Following Exercise Reduces Subsequent Energy Intake in Female Recreational Exercisers

, 2015
The aim of this study was to evaluate the effects of skimmed milk as a recovery drink following moderate–vigorous cycling exercise on subsequent appetite and energy intake in healthy, female recreational exercisers.
Stevenson, Emma, Emily Shaw, Emma Stevenson, James, Lewis, Rumbold, Penny, Shaw, Emily, Lewis James, Penny Rumbold   +7 more
core   +1 more source

Performance of lactating dairy cows fed sunflower or corn silages and concentrate based on citrus pulp or ground corn

Revista Brasileira de Zootecnia
This study aimed to evaluate the effect of diets containing sunflower or corn silages and concentrate based on citrus pulp or ground corn on intake, apparent digestibility, feeding behavior, microbial protein production, and production, composition, and ...
Leonardo Andrade Leite, Ronaldo Braga Reis, Patrícia Guimarães Pimentel, Helton Mattana Saturnino, Sandra Gesteira Coelho, Guilherme Rocha Moreira   +5 more
doaj   +1 more source

Spineless cactus varieties resistant to carmine cochineal (Dactylopius sp.) on the composition and sensory properties of goat milk

Acta Scientiarum: Animal Sciences, 2020
The physical-chemical characteristics and sensory attributes of milk are variable. This study aimed to evaluate how spineless cactus varieties resistant to carmine cochineal (Dactylopius sp.) influences the composition and sensory characteristics of ...
Beatriz Dantas Oliveira Fernandes, Rita de Cássia Ramos do Egypto Queiroga, Roberto Germano da Costa, Divan Soares da Silva, Mariana de Lima Maciel, Alenice Ozino Ramos, Ariosvaldo Nunes de Medeiros   +6 more
doaj   +1 more source

Application of front-face fluorescence spectroscopy as a tool for monitoring changes in milk protein concentrate powders during storage.

Journal of Dairy Science, 2018
This study investigated the feasibility of front-face fluorescence spectroscopy (FFFS) to predict the solubility index and relative dissolution index (RDI) of milk protein concentrate (MPC) powders during storage.
K. S. Babu, J. Amamcharla
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Measurement of Protein Stability in Sterile Concentrated Milk

Journal of Dairy Science, 1964
Abstract Gold sols were used to determine stability of protein to Ca ++ by adding 0.5ml of 0.01 to 0.02% protein solution to 10ml of gold sol, followed by 1.0ml of m CaCl 2 . Optical densities were determined at 535m μ after 1 hr. Reference protein solutions served as standards.
S. Nakai, H.K. Wilson, E.O. Herreid
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source