Results 101 to 110 of about 451,081 (310)

Human Milk vs. Cow’s Milk and the Evolution of Infant Formulas

, 2011
Until the early 20th century, a wet nurse was the only safe alternative to breastfeeding, one reason being that each species has a unique composition of its milk. When techniques for chemical analyses of milks and assessment of the energy requirements of
Olle Hernell, Hernell, Olle,
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Milk genomics : opportunities to improve the protein and fatty acid composition in raw milk

, 2009
Het onderzoek beschreven in dit proefschrift is uitgevoerd in het kader van Milk Genomics Initiatief en richt zich op de mogelijkheden om de eiwit- en vetzuursamenstelling in rauwe melk te verbeteren.
Heck, J.M.L.
core  

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Comparative analysis of the fatty acid profiles and milk fat globule membrane proteome in human and small ruminant colostrum and mature milk using data-independent acquisition for targeted infant nutrition improvement

Journal of Dairy Science
: Small ruminant milk may offer a viable alternative to cow milk, whereas human milk, the gold standard for infant nutrition, exhibits dynamic composition.
Zhongyuan Ji, Rongwei Han, Yankun Zhao, Lu Meng, Yongxin Yang, Jiaqi Wang, Nan Zheng   +6 more
doaj   +1 more source

Analysis of Nucleosides and Nucleotides in Milk and Infant Formula

, 2013
Nucleotides have been routinely supplemented to infant formulas due to the important roles they play in metabolism and to replicate the higher concentrations typically found in human milk.
Gill, Brendon D.
core  

The Comparative Genomics of Monotremes, Marsupials, and Pinnipeds: Models to Examine the Functions of Milk Proteins

, 2014
Milk has many functions, ranging from the provision of factors crucial to the operation of the mammary gland and the development of the suckled young through to their protection from infection.
Amit Kumar, Kevin R. Nicholas, Bisana, Swathi, Modepalli, Vengama, Rod Collins, Sharp, Julie A., Nicholas, Kevin R., Joly Kwek, Wanyonyi, Stephen, Collins, Rod, Julie A. Sharp, Kwek, Joly, Ashalyn Watt, Christophe Lefèvre, Watt, Ashalyn, Vengama Modepalli, Swathi Bisana, Kumar, Amit, Lefevre, Christopher, Stephen Wanyonyi   +19 more
core   +1 more source

Alterations in Whey Protein Abundance Correlated with the Somatic Cell Count Identified via Label-Free and Selected Reaction Monitoring Proteomic Approaches

Animals
The somatic cell count (SCC) is widely used to assess milk quality and diagnose intramammary infections. Several whey proteins have been shown to correlate significantly with SCC and are considered potential indicators of udder health.
Jing Li, Kaixu Chen, Changjiang Zang, Xiaowei Zhao, Zhiqiang Cheng, Xiaobin Li, Caidie Wang, Yong Chen, Kailun Yang   +8 more
doaj   +1 more source