Results 101 to 110 of about 2,360,032 (261)

Gastrointestinal-active oligosaccharides from human milk and functional foods [PDF]

open access: yes, 2011
Keywords: human milk oligosaccharides (HMOs), galacto-oligosaccharides (GOS), konjac glucomannan (KGM), breast milk, baby feces, gastrointestinal metabolization, blood-group specific conjugates, CE-LIF-MSn Oligosaccharides, as present in human milk ...
Albrecht, S.A.
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Use of proteomic methodology for the characterization of human milk fat globular membrane proteins

open access: yes, 2002
Characterization of the major human milk fat globular membrane proteins was carried out using proteomic techniques comprising two-dimensional polyacrylamide gel electrophoresis, followed by in situ PNGase F and trypsin digestion.
Charlwood, J.   +5 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source

Comparative analysis of the fatty acid profiles and milk fat globule membrane proteome in human and small ruminant colostrum and mature milk using data-independent acquisition for targeted infant nutrition improvement

open access: yesJournal of Dairy Science
: Small ruminant milk may offer a viable alternative to cow milk, whereas human milk, the gold standard for infant nutrition, exhibits dynamic composition.
Zhongyuan Ji   +6 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

Alterations in Whey Protein Abundance Correlated with the Somatic Cell Count Identified via Label-Free and Selected Reaction Monitoring Proteomic Approaches

open access: yesAnimals
The somatic cell count (SCC) is widely used to assess milk quality and diagnose intramammary infections. Several whey proteins have been shown to correlate significantly with SCC and are considered potential indicators of udder health.
Jing Li   +8 more
doaj   +1 more source

IMPACT OF MILK COOPERATIVES ON MARKETED SURPLUS OF MILK [PDF]

open access: yes
The study conducted during 1994-95 in Jalgaon and Kolhapur districts of Maharashtra showed two differing scenarios insofar as the impact of milk cooperatives on production and marketed surplus is concerned.
Shah, Deepak
core  

Effect of processing on cow’s milk protein microstructure and peptide profile released after in vitro gastrointestinal digestion [PDF]

open access: yes
Cow’s milk is an important part of the human diet, primarily due to its high nutritional content, particularly proteins and fats. Milk processing enhances safety while modifying composition and structure, influencing bioactive peptide release, which ...
Michael, Nicholas   +7 more
core   +1 more source

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