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Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer

Advanced Science, EarlyView.
In the study, UBE2C was found to be significantly overexpressed in breast cancer and transcriptionally regulated by FOXM1. Inhibition of UBE2C suppressed proliferation, induced senescence, and sensitized breast cancer cells to doxorubicin. Mechanistically, UBE2C inhibition promoted Parkin‐mediated K63‐linked ubiquitination of TOP2A.
Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang, Guanhua Du, Yumin Wang, Jinhua Wang   +12 more
wiley   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

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Secretion of Milk Proteins

Journal of Mammary Gland Biology and Neoplasia, 1998
Mammary epithelial cells secrete milk proteins in a polarized manner from their apical surface during lactation. These secreted proteins are either synthesized by the mammary cells or are transported by transcytosis from blood plasma. The intracellular trafficking pathways by which milk proteins are secreted are known in general outline. In this review
Jennifer Duncan, Robert D. Burgoyne
openaire   +3 more sources

Intolerance to milk protein

The Journal of Pediatrics, 1969
Six cases of gastrointestinal milk allergy were investigated. Vomiting with or without shocklike symptoms, failure to thrive, and diarrhea were the presenting symptoms. In 5 of the 6 patients, beta lactoglobulin was toxic; in 4 of these it was the only toxic protein.
S. Freier, S. Freier, Miriam Geifman, Miriam Geifman, E. Lebenthal, E. Lebenthal, B. Kletter, B. Kletter, I. Gery, I. Gery   +9 more
openaire   +3 more sources

Quantitation of Proteins in Milk and Milk Products

2003
This review is an update of a previous chapter published by Ribadeau-Dumas and Grappin (1992). It mostly deals with the current and recently published techniques for analysis of protein in milk and other dairy products, as well as those that could eventually come into general use.
Tremblay, L., Laporte, M.F., Leonil, Joëlle, Dupont, Didier, Paquin, P.   +4 more
openaire   +3 more sources

Milk Proteins | Lactoferrin

2002
v ; 2012 ...
Korhonen, Hannu, Marnila, Pertti
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Decomposition of Milk Proteins by Milk Protease

Agricultural and Biological Chemistry, 1972
Decomposition of major milk protein fractions by milk protease was investigated by determination of liberated tyrosine and by polyacrylamide gel electrophoresis (PAE). The rate of liberation of tyrosine from unfractionated casein, αs-casein and κ-casein was similar, but that from β-casein was about half of that from other caseins.
Kunio Yamauchi, Shuichi Kaminogawa
openaire   +2 more sources

Passage of cows' milk protein in breast milk

Clinical & Experimental Allergy, 1984
SummaryAn enzyme‐linked immunosorbent assay has been used to search for lactoglobulin and bovine casein in breast milk. Initial results suggest this may be a simple and useful method for such studies. Detection and prevention of antigen passage could influence the prevalence of atopic disease.
D. W. Hide, C. A. Stuart, R. Twiselton, M. K. Nicholas   +3 more
openaire   +2 more sources

Cow's milk proteins in human milk.

Journal of biological regulators and homeostatic agents, 2012
Cow's milk proteins (CMPs) are among the best characterized food allergens. Cow's milk contains more than twenty five different proteins, but only whey proteins alpha-lactalbumin, beta-lactoglobulin, bovine serum albumin (BSA), and lactoferrin, as well as the four caseins, have been identified as allergens.
Coscia A, Orrù S, Di Nicola P, GIULIANI, FRANCESCA, Rovelli I, Peila C, MARTANO, Claudio, Chiale F, BERTINO, Enrico   +8 more
openaire   +2 more sources