Results 91 to 100 of about 28,520 (293)

Strong Dark Matter Self-interactions Diversify Halo Populations within and surrounding the Milky Way

The Astrophysical Journal, 2023
We perform a high-resolution cosmological zoom-in simulation of a Milky Way (MW)–like system, which includes a realistic Large Magellanic Cloud analog, using a large differential elastic dark matter self-interaction cross section that reaches ≈100 cm ^2 ...
Daneng Yang, Ethan O. Nadler, Hai-Bo Yu
doaj   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

The Dark Disk of the Milky Way

, 2009
Massive satellite accretions onto early galactic disks can lead to the deposition of dark matter in disk-like configurations that co-rotate with the galaxy. This phenomenon has potentially dramatic consequences for dark matter detection experiments.
Bruch, Chris W. Purcell, Conroy, Gilmore, Gomez, Hammer, James S. Bullock, Jurić, Kazantzidis, Manoj Kaplinghat, Moster, Purcell, Purcell, Stewart, Widrow, Wyse   +15 more
core   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Importance of Initial Condition on Bar Secular Evolution: Role of Halo Angular Momentum Distribution Discontinuity

The Astrophysical Journal
The dark matter halo properties, for example, mass, spin, and concentration, play a significant role in the formation and evolution of bars in disk galaxies.
Sandeep Kumar Kataria, Juntai Shen
doaj   +1 more source

Cores in Dwarf Galaxies from Dark Matter with a Yukawa Potential

, 2010
We show that cold dark matter particles interacting through a Yukawa potential could naturally explain the recently observed cores in dwarf galaxies without affecting the dynamics of objects with a much larger velocity dispersion, such as clusters of ...
A. Loeb, Abraham Loeb, Neal Weiner
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Ursa Major III/UNIONS 1: The Darkest Galaxy Ever Discovered?

The Astrophysical Journal
The recently discovered stellar system Ursa Major III/UNIONS 1 (UMa3/U1) is the faintest known Milky Way satellite to date. With a stellar mass of ${16}_{-5}^{+6}\,{M}_{\odot }$ and a half-light radius of 3 ± 1 pc, it is either the darkest galaxy ever ...
Raphaël Errani, Julio F. Navarro, Simon E. T. Smith, Alan W. McConnachie   +3 more
doaj   +1 more source

On the phase-space structure of the Milky Way dark-matter halo

, 2001
4 pages, 5 figures, uses dunk2001_asp.sty, to appear in "The Dynamics, Structure and History of Galaxies: A Workshop in Honour of Prof. Ken Freeman", (eds) G. S. Da Costa & E. M.
Helmi, Amina, Springel, Volker, White, Simon D.~M.   +2 more
openaire   +3 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source