Results 101 to 110 of about 28,520 (293)

The shape of dark matter haloes in the Aquarius simulations: Evolution and memory

EPJ Web of Conferences, 2012
We use the high resolution cosmological N-body simulations from the Aquarius project to investigate in detail the mechanisms that determine the shape of Milky Way-type dark matter haloes.
Sales L.V., Helmi A., Vera-Ciro C.A.
doaj   +1 more source

Do the Unidentified EGRET Sources Trace Annihilating Dark Matter in the Local Group?

, 2004
In a cold dark matter (CDM) framework of structure formation, the dark matter haloes around galaxies assemble through successive mergers with smaller haloes.
A. Klypin, B. Moore, B. Moore, D. Sowards-Emmerd, D.F. Torres, D.N. Spergel, F. Prada, F. Prada, G. Hobbs, G.E. Romero, J. Cortina, J. E. Taylor, J. Flix, J. Silk, J.F. Navarro, J.M. Paredes, L. Bergstrom, L. Blitz, M. Martínez, M. Putman, M. Putman, M.L. Mateo, N. Gehrels, N.F. Martin, P. Benaglia, P. Goldoni, P. Gondolo, P.L. Nolan, R. Braun, R.C. Hartman, T. Robishaw, V. de Heij, V. de Heij   +32 more
core   +2 more sources

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

The impact of baryonic discs on the shapes and profiles of self-interacting dark matter halos

, 2018
We employ isolated N-body simulations to study the response of self-interacting dark matter (SIDM) halos in the presence of the baryonic potentials. Dark matter self-interactions lead to kinematic thermalization in the inner halo, resulting in a tight ...
Creasey, Peter, Sales, Laura V., Sameie, Omid, Vogelsberger, Mark, Yu, Hai-Bo, Zavala, Jesus   +5 more
core   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

GD-1 Stellar Stream and Cocoon in the DESI Early Data Release

The Astrophysical Journal
We present  ∼115 new spectroscopically identified members of the GD-1 tidal stream observed with the 5000-fiber Dark Energy Spectroscopic Instrument (DESI).
M. Valluri, P. Fagrelius, S. E. Koposov, T. S. Li, Oleg Y. Gnedin, E. F. Bell, R. G. Carlberg, A. P. Cooper, J. Aguilar, S. Ahlen, C. Allende Prieto, V. Belokurov, L. Beraldo e Silva, D. Brooks, A. Byström, T. Claybaugh, K. Dawson, A. Dey, P. Doel, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, J. Han, K. Honscheid, T. Kisner, A. Kremin, A. Lambert, M. Landriau, L. Le Guillou, M. E. Levi, A. de la Macorra, M. Manera, P. Martini, G. E. Medina, A. Meisner, R. Miquel, J. Moustakas, A. D. Myers, J. Najita, C. Poppett, F. Prada, M. Rezaie, G. Rossi, A. H. Riley, E. Sanchez, D. Schlegel, M. Schubnell, D. Sprayberry, G. Tarlé, G. Thomas, B. A. Weaver, R. H. Wechsler, R. Zhou, H. Zou   +53 more
doaj   +1 more source

Astrophysical Uncertainties in the Cosmic Ray Electron and Positron Spectrum From Annihilating Dark Matter

, 2009
In recent years, a number of experiments have been conducted with the goal of studying cosmic rays at GeV to TeV energies. This is a particularly interesting regime from the perspective of indirect dark matter detection.
, , A.D. Panov ., A.M. Lionetto, A.W. Strong, ATIC collaboration, D. Hooper, D. Hooper, D. Hooper, D. Maurin, D.J. Phalen, Dan Hooper, F.A. Aharonian, G.A. de Nolfo ., H. Yan, H. Yuksel, HEAT collaboration, I. Buesching, I. Cholis, I. Cholis, I. Cholis, I.V. Moskalenko, J. Connell, J.C. Benegas, J.H. Caldwell, J.H. Chappell, J.J. Engelmann ., L. Bergstrom, L. Bergström, M. Boezio ., M. Cirelli, M. Garcia-Munoz, M.A. DuVernois, M.A. DuVernois ., Melanie Simet, N. Lund, N.E. Yanasak ., P. Blasi, P. Blasi, P. Gondolo, P. Grajek, P. Grajek, R. Harnik, S. Profumo, S. Torii ., T. Delahaye ., T. Hams ., T. Sjöstrand ., T.A. Porter ., V. Barger, V.S. Berezinskii ., W.R. Webber, W.R. Webber, W.R. Webber, W.R. Webber, Y. Nomura   +55 more
core   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Disk Heating, Galactoseismology, and the Formation of Stellar Halos

Galaxies, 2017
Deep photometric surveys of the Milky Way have revealed diffuse structures encircling our Galaxy far beyond the “classical” limits of the stellar disk. This paper reviews results from our own and other observational programs, which together suggest that,
Kathryn V. Johnston, Adrian M. Price-Whelan, Maria Bergemann, Chervin Laporte, Ting S. Li, Allyson A. Sheffield, Steven R. Majewski, Rachael S. Beaton, Branimir Sesar, Sanjib Sharma   +9 more
doaj   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source