Results 141 to 150 of about 28,520 (293)

A Model-independent Radio Telescope Dark Matter Search in the L and S Bands

The Astrophysical Journal Letters
Ultralight bosonic dark matter in its most general form can be detected through its decay or annihilation to a quasimonochromatic radio line. Assuming only that this line is consistent with the most general properties of the expected phase space of our ...
Aya Keller, Nicole Wolff, Karl van Bibber   +2 more
doaj   +1 more source

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

Millimeter-wave CO and SiO Observations toward the Broad-velocity-width Molecular Feature CO 16.134–0.553: A Smith Cloud Scenario?

The Astrophysical Journal
We report the results of the CO J = 1–0 and SiO J = 2–1 mapping observations toward the broad-velocity-width molecular feature (BVF) CO 16.134–0.553 with the Nobeyama Radio Observatory 45 m telescope.
Hiroki Yokozuka, Tomoharu Oka, Shiho Tsujimoto, Yuto Watanabe, Miyuki Kaneko   +4 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Constraining the Milky Way dark matter halo with LMC-induced reflex motion

Monthly Notices of the Royal Astronomical Society
ABSTRACT Modelling perturbations of the Milky Way (MW) halo induced by the infall of the Large Magellanic Cloud (LMC) offers new avenues to constrain the dark matter (DM) distribution in our Galaxy. A key observable is the reflex motion of the Milky Way disc with respect to the halo induced by the LMC’s infall, which imprints a ...
Rashid Yaaqib, Michael S Petersen, Jorge Peñarrubia   +2 more
openaire   +2 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

GD-1 and the Milky Way Starless Dark Matter Subhalos

The Astrophysical Journal
Measurements of the GD-1 star stream velocity distribution within ±3° of the centerline find a total line-of-sight velocity spread of 5–6 km s ^−1 in the-well measured ϕ _1  = [−30, 0] region.
Raymond G. Carlberg
doaj   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

COZMIC. II. Cosmological Zoom-in Simulations with Fractional non-CDM Initial Conditions

The Astrophysical Journal
We present 24 cosmological dark matter (DM)-only zoom-in simulations of a Milky Way analog with initial conditions appropriate for scenarios where non-cold dark matter (NCDM) is a fraction of the total DM abundance (f-NCDM models) as the second ...
Rui An, Ethan O. Nadler, Andrew Benson, Vera Gluscevic   +3 more
doaj   +1 more source