Results 81 to 90 of about 28,520 (293)

Near‐Infrared‐Driven Metal–Organic Frameworks‐Based Nanorobots for Controlled Photothermal‐Chemical Therapy Synergistic Induction of Cancer Cell Death

Advanced Robotics Research, EarlyView.
To achieve efficient cancer cell death, a bowl‐shaped PDA@UiO‐66@DOX nanorobot drug‐delivery nanoplatform was developed. Near‐infrared irradiation not only drives the nanorobot to exhibit self‐thermophoretic motion and elevates temperature but also triggers Doxorubicin (DOX) release via hyperthermia, enhancing cancer cells uptake of DOX and thereby ...
Tong Lin, Jie Yang, Yongcheng Li, Yuepeng Cai, Xiaosong Zhou, Ting Chen, Renfeng Dong   +6 more
wiley   +1 more source

CONSTRAINTS ON THE SHAPE OF THE MILKY WAY DARK MATTER HALO FROM THE SAGITTARIUS STREAM [PDF]

The Astrophysical Journal, 2013
We propose a new model for the dark matter halo of the Milky Way that fits the properties of the stellar stream associated with the Sagittarius dwarf galaxy. Our dark halo is oblate with q_z = 0.9 for r < 10 kpc, and can be made to follow the Law & Majewski model at larger radii.
Vera-Ciro, Carlos, Helmi, Amina
openaire   +2 more sources

Dark Matter Direct Search Rates in Simulations of the Milky Way and Sagittarius Stream

, 2012
We analyze self-consistent N-body simulations of the Milky Way disk and the ongoing disruption of the Sagittarius dwarf satellite to study the effect of Sagittarius tidal debris on dark matter detection experiments. In agreement with significant previous
Purcell, Chris W., Wang, Mei-Yu, Zentner, Andrew R.   +2 more
core   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Baryonic impact on the dark matter orbital properties of Milky Way-sized haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 2017
12 pages, 9 ...
Zhu Q, Hernquist L, Marinacci F, Springel V, Li Y   +4 more
openaire   +3 more sources

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

The Milky Way's Inner Halo: Stellar Halo & Dark Matter Halo

, 2019
This presentation reviews the dynamical properties and origin of the stellar halo, and the distribution of dark matter in the inner Milky Way.
openaire   +1 more source

Is the Sgr dSph a dark matter dominated system?

, 2012
We study the evolution of possible progenitors of Sgr dSph}using several numerical N-body simulations of different dwarf spheroidal galaxies both with and without dark matter, as they orbit the Milky Way.
Aarseth, Aarseth, Alard, Belokurov, Binney, C.A. Martínez-Barbosa, Casas, Comerford, Cordier, Dinescu, Fellhauer, Giuffrida, Gómez-Flechoso, Helmi, Helmi, Hernquist, Ibata, Ibata, Ibata, Ibata, Ibata, Ing-Guey, Irwin, Irwin, Johnston, Johnston, Keller, Klessen, Klimentowski, Law, Law, Law, Lokas, Majewski, Majewski, Martínez-Delgado, Martínez-Delgado, Mashchenko, Mateo, Miyamoto, Newberg, Newberg, Niederste-Ostholt, Oguri, Peñarrubia, Plummer, R.A. Casas-Miranda, Springel, Watkins, Yanny   +49 more
core   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Bar-driven Streaming Motions Mimic a Massive Bulge in the Inner Milky Way

The Astrophysical Journal
The circular speed curve of the Milky Way provides a key constraint on its mass distribution, reflecting the axisymmetric component of the gravitational potential.
Junichi Baba
doaj   +1 more source