Results 71 to 80 of about 92,409 (330)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
DISCOVERY OF RR LYRAE STARS IN THE NUCLEAR BULGE OF THE MILKY WAY [PDF]
, 2016 Indexación: Web of ScienceGalactic nuclei, such as that of the Milky Way, are extreme regions with high stellar densities, and in most cases, the hosts of a supermassive black hole.
Gonzalez, OA +6 more
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars
The Astrophysical Journal Supplement SeriesA detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun +3 more
doaj +1 more source
High-resolution Chemical Abundances of the Nyx Stream
The Astrophysical Journal, 2023 Nyx is a nearby, prograde, and high-eccentricity stellar stream physically contained in the thick disk, but its origin is unknown. Nyx could be the remnant of a disrupted dwarf galaxy, in which case the associated dark matter substructure could affect ...
Shuyu Wang +7 more
doaj +1 more source
The imprint of bursty star formation on alpha-element abundance patterns in Milky Way-like galaxies [PDF]
, 2023 Hanna Parul +7 more
openalex +1 more source
Traces of the formation history of the Milky Way [PDF]
Proceedings of the International Astronomical Union, 2013 AbstractChemical and kinematical information is needed in order to understand and trace the formation history of our Galaxy. In the homogeneous large sample of F and G stars in the survey by Nordström et al. (2004), groups of stars with orbital parameters different from field stars were found by Helmi et al. (2006).
Nordström, Birgitta +3 more
openaire +2 more sources
, 2016 Quenching, the cessation of star formation, is one of the most significant events in the life cycle of galaxies. We show here the first evidence that the Milky Way experienced a generalised quenching of its star formation at the end of its thick disk ...
Di Matteo, P. +6 more
core +2 more sources
The importance of preventive feedback: inference from observations of the stellar masses and metallicities of Milky Way dwarf galaxies [PDF]
, 2017 Dwarf galaxies are known to have remarkably low star formation efficiency due to strong feedback. Adopting the dwarf galaxies of the Milky Way as a laboratory, we explore a flexible semi-analytic galaxy formation model to understand how the feedback ...
Benson, Andrew +7 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source