Results 71 to 80 of about 90,260 (324)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

Are Disks of Satellites Comprised of Tidal Dwarf Galaxies?

Galaxies, 2021
It was found that satellites of nearby galaxies can form flattened co-rotating structures called disks of satellites or planes of satellites. Their existence is not expected by the current galaxy formation simulations in the standard dark matter-based ...
Michal Bílek, Ingo Thies, Pavel Kroupa, Benoit Famaey   +3 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Additional Evidence for the Existence of a Primordial Disk System

The Astrophysical Journal
The origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu, Haibo Yuan, Bowen Huang, Timothy C. Beers, Yang Huang, Maosheng Xiang, Kai Xiao, Jihye Hong, Young Sun Lee, Wuming Yang   +9 more
doaj   +1 more source

Chemo-spectrophotometric evolution of spiral galaxies: I. The model and the Milky Way [PDF]

, 1999
The chemical and spectro-photometric evolution of spiral galaxies is investigated with detailed models, making use of up-to-date ingredients (like metallicity dependent stellar properties) and a prescription for the star formation rate (SFR) justified ...
Allard, Allen, Anders, Arimoto, Baraffe, Bazan, Bessell, Bethe, Bethe, Boesgaard, Bohlin, Boissier, Bruzual, Calzetti, Cappellaro, Cardelli, Carigi, Chamcham, Charbonnel, Charbonnel, Chiapini, Clarke, Contardo, Coppi, Corradi, Cunha, Dame, Dopita, Dwek, Edvardsson, Ferrini, Firmani, Fluks, Freudenreich, Gilmore, Gilmore, Gilmore, Gizis, Gould, Grevesse, Guibert, Guiderdoni, Guiderdoni, Gummersbach, Gusten, Han, Haywood, Iben, Israelian, Jimenez, Kennicutt, Kennicutt, Kent, Kroupa, Kroupa, Kuchinski, Kulkarni, Kurucz, Köppen, Lacey, Larson, Lejeune, Lilly, Lyne, Marigo, Massey, Massey, Matteucci, Matteucci,, Mayor, Mera, Molla, N. Prantzos, Natta, Nomoto, Onihishi, Pagel, Prantzos, Prantzos, Prantzos, Prantzos, Prantzos, Prantzos, Prantzos, Rana, Reid, Renzini, Robin, Rocha-Pinto, Rocha-Pinto, Romani, Ruiz-Lapuente, Ruphy, S. Boissier, Sackett, Salpeter, Samland, Scalo, Scalo, Schaller, Shaver, Smart, Steinmetz, Talbot, Tammann, Thielemann, Thielemann, Thomas, Thorsett, Timmes, Tinsley, Tosi, Tosi, Tsujimoto, van der Kruit, Vilchez, Wang, Wang, Wang, Woosley, Wyse, Wyse, Xu   +122 more
core   +4 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way

The Astrophysical Journal
The search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin, Alessandro Spagna, Mario G. Lattanzi, Michele Cignoni, Sara Vitali   +4 more
doaj   +1 more source

When the Milky Way turned off the lights: APOGEE provides evidence of star formation quenching in our Galaxy

, 2016
Quenching, the cessation of star formation, is one of the most significant events in the life cycle of galaxies. We show here the first evidence that the Milky Way experienced a generalised quenching of its star formation at the end of its thick disk ...
Di Matteo, P., Gomez, A., Haywood, M., Katz, D., Lehnert, M. D., Schultheis, M., Snaith, O.   +6 more
core   +2 more sources

A low pre-infall mass for the Carina dwarf galaxy from disequilibrium modelling [PDF]

, 2015
Dark matter only simulations of galaxy formation predict many more subhalos around a Milky Way like galaxy than the number of observed satellites. Proposed solutions require the satellites to inhabit dark matter halos with masses between one to ten ...
Read, Justin I., Ural, Uğur, Walker, Matthew G., Wilkinson, Mark I.   +3 more
core   +2 more sources