Results 81 to 90 of about 90,260 (324)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

High-resolution Chemical Abundances of the Nyx Stream

The Astrophysical Journal, 2023
Nyx is a nearby, prograde, and high-eccentricity stellar stream physically contained in the thick disk, but its origin is unknown. Nyx could be the remnant of a disrupted dwarf galaxy, in which case the associated dark matter substructure could affect ...
Shuyu Wang, Lina Necib, Alexander P. Ji, Xiaowei Ou, Mariangela Lisanti, Mithi A. C. de los Reyes, Allison L. Strom, Mimi Truong   +7 more
doaj   +1 more source

The Dichotomy of the Halo of the Milky Way

, 2008
We summarize evidence that the halo of the Milky Way comprises two different, and broadly overlapping, stellar components. The two structures exhibit different chemical compositions, spatial distributions, and kinematics.
Akira Ohnishi, Daniela Carollo, Kiyoshi Kato, Masayuki Y. Fujimoto, Shigeru Kubono, Takaya Nozawa, Takuma Suda, Timothy C. Beers, Toshitaka Kajino   +8 more
core   +1 more source

The importance of preventive feedback: inference from observations of the stellar masses and metallicities of Milky Way dwarf galaxies [PDF]

, 2017
Dwarf galaxies are known to have remarkably low star formation efficiency due to strong feedback. Adopting the dwarf galaxies of the Milky Way as a laboratory, we explore a flexible semi-analytic galaxy formation model to understand how the feedback ...
Benson, Andrew, Boylan-Kolchin, Michael, Lu, Yu, Mao, Yao-Yuan, Peter, Annika H. G., Tonnesen, Stephanie, Wechsler, Risa, Wetzel, Andrew   +7 more
core   +2 more sources

Constraining the thick disc formation scenario of the Milky Way [PDF]

Astronomy & Astrophysics, 2014
We study the shape of the thick disc using photometric data at high and intermediate latitudes from SDSS and 2MASS surveys. We use the population synthesis approach using an ABC-MCMC method to characterize the thick disc shape, scale height, scale length, local density and flare, and we investigate the extend of the thick disc formation period by ...
A. M. M. Martins, J. Fliri, J. Fliri, M. Czekaj, Christian P. Robert, Céline Reylé, Annie C. Robin   +6 more
openaire   +6 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars

The Astrophysical Journal Supplement Series
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu   +3 more
doaj   +1 more source

4MOST Consortium Survey 3: Milky Way Disc and Bulge Low-Resolution Survey (4MIDABLE-LR)

, 2019
The mechanisms of the formation and evolution of the Milky Way are encoded in the orbits, chemistry and ages of its stars. With the 4MOST MIlky way Disk And BuLgE Low-Resolution Survey (4MIDABLE-LR) we aim to study kinematic and chemical substructures in
Anders, F., Andrae, R., Arentsen, A., Asplund, M., Bensby, T., Bergemann, M., Casagrande, L., Cescutti, G., Chiappini, C., Church, R., Feltzing, S., Fouesneau, M., Fusillo, N., Gerhard, O., Grebel, E., Guiglion, G., Khalatyan, A., Kordopatis, G., Kovalev, M., Lemasle, B., Matijevic, G., McMillan, P., Minchev, I., Monari, G., Queiroz, A., Rix, H., Rybizki, J., Ryde, N., Schwope, A., Starkenburg, E., Steinmetz, M., Storm, J., Team, 4., Traven, G., Tremblay, P., Valentini, M., Walton, N., Xiang, M., Zucker, D.   +38 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source