Results 81 to 90 of about 267,615 (357)

Formation Imprints in the Kinematics of the Milky Way Globular Cluster System [PDF]

Astrophysical Journal, 2019
We report results on the kinematics of Milky Way (MW) globular clusters (GCs) based on updated space velocities for nearly the entire GC population. We found that a 3D space with the semimajor axis, the eccentricity, and the inclination of the orbit with
A. Piatti
semanticscholar   +1 more source

Formation, vertex deviation, and age of the Milky Way’s bulge: input from a cosmological simulation with a late-forming bar [PDF]

Monthly notices of the Royal Astronomical Society, 2018
We present the late-time evolution of m12m, a cosmological simulation of a Milky Way-like galaxy from the FIRE project. The simulation forms a bar after redshift z = 0.2.
V. Debattista, O. Gonzalez, R. Sanderson, K. El-Badry, S. Garrison-Kimmel, A. Wetzel, C. Faucher-Giguére, P. Hopkins   +7 more
semanticscholar   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

The Three-phase Evolution of the Milky Way

The Astrophysical Journal
We illustrate the formation and evolution of the Milky Way over cosmic time, utilizing a sample of 10 million red giant stars with full chemodynamical information, including metallicities and α -abundances from low-resolution Gaia XP spectra.
Vedant Chandra, Vadim A. Semenov, Hans-Walter Rix, Charlie Conroy, Ana Bonaca, Rohan P. Naidu, René Andrae, Jiadong Li, Lars Hernquist   +8 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Are Disks of Satellites Comprised of Tidal Dwarf Galaxies?

Galaxies, 2021
It was found that satellites of nearby galaxies can form flattened co-rotating structures called disks of satellites or planes of satellites. Their existence is not expected by the current galaxy formation simulations in the standard dark matter-based ...
Michal Bílek, Ingo Thies, Pavel Kroupa, Benoit Famaey   +3 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The Formation of the Milky Way Disk

, 2000
We present theoretical results on the galactic abundance gradients of several chemical species for the Milky Way disk, obtained using an improved version of the two-infall model of Chiappini, Matteucci, & Gratton (1997) that incorporates a more realistic model of the galactic halo and disk.
Chiappini, Cristina, Matteucci, Francesca, Romano, Donatella   +2 more
openaire   +2 more sources

Galactic Archaeology with asteroseismic ages: Evidence for delayed gas infall in the formation of the Milky Way disc [PDF]

Astronomy & Astrophysics, 2018
Context. Precise stellar ages from asteroseismology have become available and can help to set stronger constraints on the evolution of the Galactic disc components.
E. Spitoni, V. S. Aguirre, F. Matteucci, F. Calura, V. Grisoni   +4 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source